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Literature summary extracted from

  • Takeya, C.; Esumi, M.; Shiroishi, T.; Hishida, R.; Yamamoto, T.
    Multiple single-nucleotide polymorphisms in the methylenetetrahydrofolate reductase and its truncated pseudogene of 23 inbred strains of mice (2003), Biochem. Biophys. Res. Commun., 312, 480-486.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.15 S-adenosyl-L-methionine allosteric inhibitor, enzyme contains a binding site at the C-terminus Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.1.15 additional information Mus musculus enzyme deficiency results in a number of diseases ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.15 Mus musculus Q9WU20 gene mthfr
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.15 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.15 5,10-methylenetetrahydrofolate + NAD+ N-terminal catalytic domain Mus musculus 5,10-methenyltetrahydrofolate + NADH
-
 ?
1.5.1.15 additional information enzyme deficiency results in a number of diseases Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.5.1.15 5,10-methylenetetrahydrofolate reductase
-
 Mus musculus
1.5.1.15 MTHFR
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.15 FAD required for enzyme stability, binding site comprises amino acid residues 95-228 Mus musculus
1.5.1.15 NAD+
-
 Mus musculus