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Literature summary extracted from

  • Gong, H.; Byers, D.M.
    Glutamate-41 of Vibrio harveyi acyl carrier protein is essential for fatty acid synthase but not acyl-ACP synthetase activity (2003), Biochem. Biophys. Res. Commun., 302, 35-40.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.86 A45C about 5% reduction in overall enzyme activity Vibrio harveyi
2.3.1.86 A45G about 15% reduction in overall enzyme activity Vibrio harveyi
2.3.1.86 A45W about 10% reduction in overall enzyme activity Vibrio harveyi
2.3.1.86 E41D about 10% reduction in overall enzyme activity Vibrio harveyi
2.3.1.86 E41K no residual activity Vibrio harveyi
2.3.1.86 V43I no reduction in overall enzyme activity Vibrio harveyi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.20 ATP + an acid + [acyl-carrier protein] Vibrio harveyi synthesis of activated acyl-carrier protein that is essential as a carrier of acyl-intermediates and donor for activated acyl groups for the synthesis of lipids and lipid derivatives AMP + diphosphate + acyl-[acyl-carrier protein]
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Organism

EC Number Organism UniProt Comment Textmining
2.3.1.86 Vibrio harveyi
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6.2.1.20 Vibrio harveyi
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Purification (Commentary)

EC Number Purification (Comment) Organism
6.2.1.20 partial Vibrio harveyi

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.20 ATP + an acid + [acyl-carrier protein] synthesis of activated acyl-carrier protein that is essential as a carrier of acyl-intermediates and donor for activated acyl groups for the synthesis of lipids and lipid derivatives Vibrio harveyi AMP + diphosphate + acyl-[acyl-carrier protein]
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 ?
6.2.1.20 ATP + an acid + [acyl-carrier protein] mutations E41D, E41K, A45G, A45C, A45W and V43I in acyl-carrier protein have only minor effects on activity Vibrio harveyi AMP + diphosphate + acyl-[acyl-carrier protein]
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