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Literature summary extracted from

  • Krahenbuhl, S.; Brass, E.P.
    Inhibition of hepatic propionyl-CoA synthetase activity by organic acids (1991), Biochem. Pharmacol., 41, 1015-1023.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.2.1.17 4-nitrobenzoate inhibition of propanoyl-CoA formation in solubilized mitochondria Rattus norvegicus
6.2.1.17 Butyrate inhibition of propanoyl-CoA formation in solubilized mitochondria Rattus norvegicus
6.2.1.17 Octanoate inhibition of propanoyl-CoA formation in solubilized mitochondria Rattus norvegicus
6.2.1.17 salicylate inhibition of propanoyl-CoA formation in solubilized mitochondria Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.2.1.17 mitochondrion
-
Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.17 ATP + propanoate + CoA Rattus norvegicus intracellular accumulation of propanoyl-CoA is associated with impairment of important heptic metabolic pathways. Since propanoate absorbed from the intestine can be converted to propanoyl-CoA in the liver, inhibition of propanoyl-CoA synthesis from propanoate and CoA may provide a strategy for decreasing toxicity from plasma propanoate ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.17 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.17 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.17 ATP + propanoate + CoA
-
Rattus norvegicus AMP + diphosphate + propanoyl-CoA
-
?
6.2.1.17 ATP + propanoate + CoA intracellular accumulation of propanoyl-CoA is associated with impairment of important heptic metabolic pathways. Since propanoate absorbed from the intestine can be converted to propanoyl-CoA in the liver, inhibition of propanoyl-CoA synthesis from propanoate and CoA may provide a strategy for decreasing toxicity from plasma propanoate Rattus norvegicus ?
-
?