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Literature summary extracted from
- Cocrystal structures of diaminopimelate decarboxylase: mechanism, evolution, and inhibition of an antibiotic resistance accessory factor (2002), Structure, 10, 1499-1508.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.1.1.20 | expression in Escherichia coli | Methanocaldococcus jannaschii |
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 4.1.1.20 | co-crystals of DAPDC and azelaic acid and L-lysine at 2.6 A and 2.0 A resolution, respectively, hanging drop vapor-diffusion, 12% polyethylene glycol 6000, 100 mm Tris-Cl, pH 8.0, 20 mM MgCl2 and 10 mM L-lysine | Methanocaldococcus jannaschii |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.20 | 1,5-Diaminopentane | - |
Methanocaldococcus jannaschii |  |
| 4.1.1.20 | 1,6-diaminohexane | - |
Methanocaldococcus jannaschii | |
| 4.1.1.20 | 1,7-Diaminoheptane | - |
Methanocaldococcus jannaschii | |
| 4.1.1.20 | adipic acid | - |
Methanocaldococcus jannaschii | |
| 4.1.1.20 | azelaic acid | - |
Methanocaldococcus jannaschii | |
| 4.1.1.20 | caproic acid | - |
Methanocaldococcus jannaschii | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.20 | 50000 | - |
x * 50000, mass spectrometry | Methanocaldococcus jannaschii |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.20 | meso-2,6-Diaminoheptanedioate | Methanocaldococcus jannaschii | last step in L-lysine biosynthesis | L-Lysine + CO2 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.1.20 | Methanocaldococcus jannaschii | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.1.1.20 | recombinant DAPDC | Methanocaldococcus jannaschii |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.20 | meso-2,6-Diaminoheptanedioate | - |
Methanocaldococcus jannaschii | L-Lysine + CO2 | - |
? | |
| 4.1.1.20 | meso-2,6-Diaminoheptanedioate | last step in L-lysine biosynthesis | Methanocaldococcus jannaschii | L-Lysine + CO2 | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.1.1.20 | ? | x * 50000, mass spectrometry | Methanocaldococcus jannaschii |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.1.1.20 | DAPDC | - |
Methanocaldococcus jannaschii |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.1.1.20 | 0.0024 | - |
1,6-diaminohexane | - |
Methanocaldococcus jannaschii | |
| 4.1.1.20 | 0.0025 | - |
1,7-Diaminoheptane | - |
Methanocaldococcus jannaschii | |
| 4.1.1.20 | 0.004 | - |
1,5-Diaminopentane | - |
Methanocaldococcus jannaschii | |
| 4.1.1.20 | 0.089 | - |
azelaic acid | - |
Methanocaldococcus jannaschii | |
| 4.1.1.20 | 0.13 | - |
adipic acid | - |
Methanocaldococcus jannaschii | |
| 4.1.1.20 | 0.21 | - |
caproic acid | - |
Methanocaldococcus jannaschii | |
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