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Literature summary extracted from

  • Qiu, X.; Janson, C.A.; Smith, W.W.; Green, S.M.; McDevitt, P.; Johanson, K.; Carter, P.; Hibbs, M.; Lewis, C.; Chalker, A.; Fosberry, A.; Lalonde, J.; Berge, J.; Brown, P.; Houge-Frydrych, C.S.; Jarvest, R.L.
    Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors (2001), Protein Sci., 10, 2008-2016.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
6.1.1.1 pharmacology design of antimicrobial agents against Staphylococcus aureus, largely responsible for hospital-acquired infections, on the basis of knowledge of the crystal structure and the revealed catalytic mechanism Staphylococcus aureus

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
6.1.1.1 crystal structure determination by X-ray diffraction, enzyme complexed with inhibitors at 2.8 A resolution, and truncated enzyme complexed with inhibitors at 2.2 A resolution Staphylococcus aureus

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.1 additional information enzyme-inhibitor complexes Staphylococcus aureus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.1 ATP + tyrosine + tRNATyr Staphylococcus aureus
-
 AMP + Tyr-tRNATyr + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.1 Staphylococcus aureus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
6.1.1.1 ATP + L-tyrosine + tRNATyr = AMP + diphosphate + L-tyrosyl-tRNATyr mechanism Staphylococcus aureus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.1 ATP + tyrosine + tRNATyr
-
 Staphylococcus aureus AMP + Tyr-tRNATyr + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.1 Tyrosine tRNA synthetase
-
 Staphylococcus aureus

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.1 ATP
-
 Staphylococcus aureus