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Literature summary extracted from

  • Boublik, Y.; Saint-Aguet, P.; Lougarre, A.; Arnaud, M.; Villatte, F.; Estrada-Mondaca, S.; Fournier, D.
    Acetylcholinesterase engineering for detection of insecticide residues (2002), Protein Eng., 15, 43-50.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.7 expressed in baculovirus Drosophila melanogaster

Protein Variants

EC Number Protein Variants Comment Organism
3.1.1.7 D375G increased sensitivity for malaoxon, omethoate and paraoxon Drosophila melanogaster
3.1.1.7 E69W increased sensitivity for carbaryl, malaoxon, omethoate and paraoxon Drosophila melanogaster
3.1.1.7 E69Y increased sensitivity for carbaryl, malaoxon, omethoate and paraoxon Drosophila melanogaster
3.1.1.7 F330I increased sensitivity for malaoxon, omethoate and paraoxon Drosophila melanogaster
3.1.1.7 F330L increased sensitivity for malaoxon, omethoate and paraoxon Drosophila melanogaster
3.1.1.7 L328F increased sensitivity for omethoate and paraoxon Drosophila melanogaster
3.1.1.7 R70V increased sensitivity for carbaryl and omethoate Drosophila melanogaster
3.1.1.7 V318D increased sensitivity for carbaryl, malaoxon and paraoxon Drosophila melanogaster
3.1.1.7 W321L increased sensitivity for carbaryl, malaoxon, omethoate and paraoxon Drosophila melanogaster
3.1.1.7 Y370A increased sensitivity for carbaryl, malaoxon, omethoate and paraoxon Drosophila melanogaster
3.1.1.7 Y370F increased sensitivity for carbaryl, malaoxon, omethoate and paraoxon Drosophila melanogaster
3.1.1.7 Y374A increased sensitivity for carbaryl, malaoxon and paraoxon Drosophila melanogaster
3.1.1.7 Y71D increased sensitivity for carbaryl, malaoxon, omethoate and paraoxon Drosophila melanogaster
3.1.1.7 Y73Q increased sensitivity for carbaryl, malaoxon, omethoate and paraoxon Drosophila melanogaster

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.7 Carbaryl
-
 Drosophila melanogaster
3.1.1.7 malaoxon
-
 Drosophila melanogaster
3.1.1.7 omethoate
-
 Drosophila melanogaster
3.1.1.7 paraoxon
-
 Drosophila melanogaster

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Drosophila melanogaster
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.7 acetylthiocholine + H2O
-
 Drosophila melanogaster thiocholine + acetate
-
 ?