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Literature summary extracted from

  • Giacobini, E.
    Cholinesterases: New roles in brain function and in Alzheimer's disease (2003), Neurochem. Res., 28, 515-522.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.7 bambuterol 50% inhibition at 0.03 mM Homo sapiens
3.1.1.7 bisnorcymserine 50% inhibition at mM Homo sapiens
3.1.1.7 cymserine inhibition in the nanomolar range Homo sapiens
3.1.1.7 donepezil inhibition in the nanomolar range Homo sapiens
3.1.1.7 eptastigmine inhibition in the nanomolar range Homo sapiens
3.1.1.7 ethopropazine 50% inhibition at 0.26 mM Homo sapiens
3.1.1.7 galantamine inhibition in the nanomolar range Homo sapiens
3.1.1.7 huperzine inhibition in the nanomolar range Homo sapiens
3.1.1.7 iso-ompa 50% inhibition at 0.034 mM Homo sapiens
3.1.1.7 metrifonate inhibition in the nanomolar range Homo sapiens
3.1.1.7 phenserine inhibition in the nanomolar range Homo sapiens
3.1.1.7 phenylethylcymserine 50% inhibition at 0.03 mM Homo sapiens
3.1.1.7 physostigmine inhibition in the nanomolar range Homo sapiens
3.1.1.7 rivastigmine 50% inhibition at 0.048 mM Homo sapiens
3.1.1.7 tacrine inhibition in the nanomolar range Homo sapiens
3.1.1.8 bambuterol inhibition in the nanomolar range Homo sapiens
3.1.1.8 bisnorcymserine inhibition in the nanomolar range Homo sapiens
3.1.1.8 cymserine inhibition in the nanomolar range Homo sapiens
3.1.1.8 donepezil 50% inhibition at 0.004 mM Homo sapiens
3.1.1.8 eptastigmine inhibition in the nanomolar range Homo sapiens
3.1.1.8 ethopropazine inhibition in the nanomolar range Homo sapiens
3.1.1.8 galantamine 50% inhibition at 0.0073 mM Homo sapiens
3.1.1.8 huperzine 50% inhibition at 0.03 mM Homo sapiens
3.1.1.8 iso-ompa inhibition in the nanomolar range Homo sapiens
3.1.1.8 metrifonate 50% inhibition at 0.018 mM Homo sapiens
3.1.1.8 phenserine 50% inhibition at 0.0015 mM Homo sapiens
3.1.1.8 phenylethylcymserine inhibition in the nanomolar range Homo sapiens
3.1.1.8 physostigmine inhibition in the nanomolar range Homo sapiens
3.1.1.8 rivastigmine 50% inhibition at 0.054 mM Homo sapiens
3.1.1.8 tacrine inhibition in the nanomolar range Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.8 additional information Homo sapiens butyrylcholine is not a physiological substrate, enzyme may replace acetylcholine esterase in hydrolysing brain acetylcholine in patients with advanced stages of Alzheimer's disease ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Homo sapiens
-
-
-
3.1.1.8 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.7 brain
-
 Homo sapiens
-
3.1.1.8 brain
-
 Homo sapiens
-
3.1.1.8 glial cell
-
 Homo sapiens
-
3.1.1.8 neuron
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.7 acetylcholine + H2O
-
 Homo sapiens choline + acetate
-
 ?
3.1.1.8 acetylcholine + H2O
-
 Homo sapiens choline + acetate
-
 ?
3.1.1.8 butyrylthiocholine + H2O
-
 Homo sapiens thiocholine + butyrate
-
 ?
3.1.1.8 additional information butyrylcholine is not a physiological substrate, enzyme may replace acetylcholine esterase in hydrolysing brain acetylcholine in patients with advanced stages of Alzheimer's disease Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.8 butyrocholinesterase
-
 Homo sapiens
3.1.1.8 ChE-II
-
 Homo sapiens
3.1.1.8 serum cholinesterase
-
 Homo sapiens