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Literature summary extracted from

  • Niedens, B.R.; Parker, S.R.; Stierle, D.B.; Stierle, A.A.
    First fungal aromatic L-amino acid decarboxylase from a paclitaxel-producing Penicillium raistrickii (1999), Mycologia, 91, 619-626.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.28 additional information not inhibited by L-alpha-fluoromethyltyrosine and L-alpha-fluoromethyl(3,4-dihydroxyphenyl)alanine Penicillium raistrickii

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.28 0.049
-
 L-tryptophan pH 5.0-5.6, 36°C Penicillium raistrickii
4.1.1.28 0.099
-
 L-phenylalanine pH 5.0-5.6, 36°C Penicillium raistrickii
4.1.1.28 1.064
-
 L-tyrosine pH 5.0-5.6, 36°C Penicillium raistrickii

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.28 125000
-
 SDS-PAGE Penicillium raistrickii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.28 L-tryptophan Penicillium raistrickii
-
 tryptamine + CO2
-
 ?
4.1.1.28 L-tryptophan Penicillium raistrickii H10BA2
-
 tryptamine + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.28 no activity in Penicillium raistrickii
-
 strain ATCC 46878
-
4.1.1.28 Penicillium raistrickii
-
 H10BA2
-
4.1.1.28 Penicillium raistrickii H10BA2
-
 H10BA2
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.28
-
 Penicillium raistrickii

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.28 additional information
-
 specific activity 10455 nkatal mg-1 Penicillium raistrickii

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.28 L-phenylalanine
-
 Penicillium raistrickii phenylethylamine + CO2
-
 ?
4.1.1.28 L-phenylalanine
-
 Penicillium raistrickii H10BA2 phenylethylamine + CO2
-
 ?
4.1.1.28 L-tryptophan
-
 Penicillium raistrickii tryptamine + CO2
-
 ?
4.1.1.28 L-tryptophan
-
 Penicillium raistrickii H10BA2 tryptamine + CO2
-
 ?
4.1.1.28 L-Tyrosine
-
 Penicillium raistrickii Tyramine + CO2
-
 ?
4.1.1.28 L-Tyrosine
-
 Penicillium raistrickii H10BA2 Tyramine + CO2
-
 ?
4.1.1.28 additional information no enzyme activity detected with D-phenylalanine, L-5-hydroxytryptophan or L-histidine Penicillium raistrickii ?
-
 ?
4.1.1.28 additional information no enzyme activity detected with D-phenylalanine, L-5-hydroxytryptophan or L-histidine Penicillium raistrickii H10BA2 ?
-
 ?
4.1.1.28 o-fluorophenylalanine
-
 Penicillium raistrickii o-fluorophenylethylamine + CO2
-
 ?
4.1.1.28 o-fluorophenylalanine
-
 Penicillium raistrickii H10BA2 o-fluorophenylethylamine + CO2
-
 ?
4.1.1.28 p-fluorophenylalanine
-
 Penicillium raistrickii p-fluorophenylethylamine + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.28 monomer 1 * 125000, SDS-PAGE Penicillium raistrickii

Synonyms

EC Number Synonyms Comment Organism
4.1.1.28 Aromatic L-amino acid decarboxylase
-
 Penicillium raistrickii

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.1.1.28 36
-
-
 Penicillium raistrickii

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.28 5 5.6
-
 Penicillium raistrickii

pI Value

EC Number Organism Comment pI Value Maximum pI Value
4.1.1.28 Penicillium raistrickii isoelectric focusing gel
-
 6.2