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Literature summary extracted from

  • Komura, H.; Shimomura, Y.; Yumoto, M.; Katsuya, H.; Okada, N.; Okada, H.
    Heat stability of carboxypeptidase R of experimental animals (2002), Microbiol. Immunol., 46, 217-223.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.3 Cavia porcellus
-
-
-
3.4.17.3 Homo sapiens
-
-
-
3.4.17.3 Oryctolagus cuniculus
-
-
-
3.4.17.3 Rattus norvegicus
-
-
-
3.4.17.20 Cavia porcellus
-
-
-
3.4.17.20 Homo sapiens
-
-
-
3.4.17.20 Oryctolagus cuniculus
-
-
-
3.4.17.20 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.17.20 proteolytic modification carboxypeptidase R is generated from pro-carboxypeptidase R by trypsin-like enzymes such as thrombin. Carboxypeptidase R regulates not only inflammatory peptides but also restricts fibrinolysis Cavia porcellus
3.4.17.20 proteolytic modification carboxypeptidase R is generated from pro-carboxypeptidase R by trypsin-like enzymes such as thrombin. Carboxypeptidase R regulates not only inflammatory peptides but also restricts fibrinolysis Homo sapiens
3.4.17.20 proteolytic modification carboxypeptidase R is generated from pro-carboxypeptidase R by trypsin-like enzymes such as thrombin. Carboxypeptidase R regulates not only inflammatory peptides but also restricts fibrinolysis Rattus norvegicus
3.4.17.20 proteolytic modification carboxypeptidase R is generated from pro-carboxypeptidase R by trypsin-like enzymes such as thrombin. Carboxypeptidase R regulates not only inflammatory peptides but also restricts fibrinolysis Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.17.3 blood plasma
-
 Cavia porcellus
-
3.4.17.3 blood plasma
-
 Homo sapiens
-
3.4.17.3 blood plasma
-
 Rattus norvegicus
-
3.4.17.3 blood plasma
-
 Oryctolagus cuniculus
-
3.4.17.20 blood serum
-
 Cavia porcellus
-
3.4.17.20 blood serum
-
 Homo sapiens
-
3.4.17.20 blood serum
-
 Rattus norvegicus
-
3.4.17.20 blood serum
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.3 hippuryl-Arg + H2O
-
 Cavia porcellus hippuric acid + Arg
-
 ?
3.4.17.3 hippuryl-Arg + H2O
-
 Homo sapiens hippuric acid + Arg
-
 ?
3.4.17.3 hippuryl-Arg + H2O
-
 Rattus norvegicus hippuric acid + Arg
-
 ?
3.4.17.3 hippuryl-Arg + H2O
-
 Oryctolagus cuniculus hippuric acid + Arg
-
 ?
3.4.17.20 hippuryl-Arg + H2O
-
 Cavia porcellus hippuric acid + Arg
-
 ?
3.4.17.20 hippuryl-Arg + H2O
-
 Homo sapiens hippuric acid + Arg
-
 ?
3.4.17.20 hippuryl-Arg + H2O
-
 Rattus norvegicus hippuric acid + Arg
-
 ?
3.4.17.20 hippuryl-Arg + H2O
-
 Oryctolagus cuniculus hippuric acid + Arg
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.4.17.3 37
-
 no loss of activity for up to 25 min Cavia porcellus
3.4.17.3 37
-
 no loss of activity for up to 25 min Homo sapiens
3.4.17.3 37
-
 no loss of activity for up to 25 min Rattus norvegicus
3.4.17.3 37
-
 no loss of activity for up to 25 min Oryctolagus cuniculus
3.4.17.20 25
-
 half-life of carboxypeptidase R: 36 min, half-life of thrombin/thrombomodulin complex activated carboxypeptidase R: 27 min Rattus norvegicus
3.4.17.20 25
-
 half-life of carboxypeptidase R: 53 min, half-life of thrombin/thrombomodulin complex activated carboxypeptidase R: 29 min Cavia porcellus
3.4.17.20 25
-
 half-life of thrombin/thrombomodulin complex activated carboxypeptidase R: 47 min Oryctolagus cuniculus
3.4.17.20 25
-
 no decay of carboxypeptidase R after 60 min, half-life of thrombin/thrombomodulin complex activated carboxypeptidase R: 139 min Homo sapiens
3.4.17.20 37
-
 half-life of carboxypeptidase R: 11 min, half-life of thrombin/thrombomodulin complex activated carboxypeptidase R: 8.3 min Cavia porcellus
3.4.17.20 37
-
 half-life of carboxypeptidase R: 16 min, half-life of thrombin/thrombomodulin complex activated carboxypeptidase R: 13 min Rattus norvegicus
3.4.17.20 37
-
 half-life of carboxypeptidase R: 18 min, half-life of thrombin/thrombomodulin complex activated carboxypeptidase R: 10 min Oryctolagus cuniculus
3.4.17.20 37
-
 half-life of carboxypeptidase R: 6.3 min, half-life of thrombin/thrombomodulin complex activated carboxypeptidase R: 9.1 min Homo sapiens