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Literature summary extracted from

  • Roos, A.K.; Andersson, C.E.; Bergfors, T.; Jacobsson, M.; Karlen, A.; Unge, T.; Jones, T.A.; Mowbray, S.L.
    Mycobacterium tuberculosis ribose-5-phosphate isomerase has a known fold, but a novel active site (2004), J. Mol. Biol., 335, 799-809.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.3.1.6 overexpression in Escherichia coli Mycobacterium tuberculosis

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
5.3.1.6 sitting drop vapour diffusion method Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.1.6 iodoacetate
-
 Mycobacterium tuberculosis
5.3.1.6 phosphate weak Mycobacterium tuberculosis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.3.1.6 3.7
-
 D-ribose 5-phosphate
-
 Mycobacterium tuberculosis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.3.1.6 17300
-
 2 * 17300, calculation from nucleotide sequence Mycobacterium tuberculosis
5.3.1.6 30000 35000 gel filtration Mycobacterium tuberculosis
5.3.1.6 32000
-
 dynamic light scattering Mycobacterium tuberculosis
5.3.1.6 34000
-
 non-denaturing PAGE Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
5.3.1.6 Mycobacterium tuberculosis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.3.1.6
-
 Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.1.6 D-ribose 5-phosphate
-
 Mycobacterium tuberculosis D-ribulose 5-phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
5.3.1.6 dimer 2 * 17300, calculation from nucleotide sequence Mycobacterium tuberculosis

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
5.3.1.6 120
-
 D-ribose 5-phosphate
-
 Mycobacterium tuberculosis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
5.3.1.6 130
-
 phosphate
-
 Mycobacterium tuberculosis