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Literature summary extracted from

  • Hanada, K.; Palacpac, N.M.Q.; Magistrado, P.A.; Kurokawa, K.; Rai, G.; Sakata, D.; Hara, T.; Horii, T.; Nishijima, M.; Mitamura, T.
    Plasmodium falciparum phospholipase C hydrolyzing sphingomyelin and lysocholinephospholipids is a possible target for malaria chemotherapy (2002), J. Exp. Med., 195, 23-34.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.3 Mg2+ required Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.3 scyphostatin 50% inhibition of parasite-growth at 0.007 mM Plasmodium falciparum
3.1.4.3 sphingomyelin competitive Plasmodium falciparum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.3 0.025
-
 1-palmitoyl-lysophosphatidylcholine pH 7.5, 37°C Plasmodium falciparum
3.1.4.3 0.09
-
 sphingomyelin pH 7.5, 37°C Plasmodium falciparum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.3 membrane associated to Plasmodium falciparum 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.4.3 46000
-
 x * 46000, deduced from gene sequence Plasmodium falciparum

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.3 Plasmodium falciparum
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.3 1-palmitoyl-lysophosphatidylcholine + H2O
-
 Plasmodium falciparum monopalmitoylglycerol + phosphorylcholine
-
 ?
3.1.4.3 lysocholinephospholipid + H2O
-
 Plasmodium falciparum ?
-
 ?
3.1.4.3 sphingomyelin + H2O
-
 Plasmodium falciparum ceramide + phosphocholine
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.4.3 ? x * 46000, deduced from gene sequence Plasmodium falciparum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.3 7.5
-
-
 Plasmodium falciparum