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Literature summary extracted from

  • Warrilow, A.G.; Hawkesford, M.J.
    Modulation of cyanoalanine synthase and O-acetylserine (thiol) lyases A and B activity by beta-substituted alanyl and anion inhibitors (2002), J. Exp. Bot., 53, 439-445.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.4.1.9 chloroalanine uncompetitive vs. L-cysteine Spinacia oleracea
4.4.1.9 cyanoalanine uncompetitive vs. O-acetyl-L-serine, noncompetitive vs. chloroalanine and L-cysteine Spinacia oleracea
4.4.1.9 homocysteine uncompetitive vs. O-acetyl-L-serine, noncompetitive vs. chloroalanine and L-cysteine Spinacia oleracea
4.4.1.9 KCN uncompetitive vs. O-acetyl-L-serine, noncompetitive vs. L-cysteine Spinacia oleracea
4.4.1.9 O-acetyl-L-serine uncompetitive vs. O-acetyl-L-serine, noncompetitive vs. chloroalanine Spinacia oleracea
4.4.1.9 sodium thiocyanate uncompetitive vs. O-acetyl-L-serine Spinacia oleracea

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.4.1.9 0.4
-
 L-cysteine
-
 Spinacia oleracea
4.4.1.9 0.54
-
 chloroalanine
-
 Spinacia oleracea
4.4.1.9 10.5
-
 O-acetyl-L-serine
-
 Spinacia oleracea

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.4.1.9 chloroalanine + sulfide Spinacia oleracea
-
 L-cysteine + Cl-
-
 ?
4.4.1.9 L-cysteine + HCN Spinacia oleracea
-
 sulfide + L-3-cyanoalanine
-
 ?
4.4.1.9 O-acetyl-L-serine + sulfide Spinacia oleracea
-
 L-cysteine + acetate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.9 Spinacia oleracea
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.4.1.9
-
 Spinacia oleracea

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.4.1.9 leaf
-
 Spinacia oleracea
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.9 chloroalanine + sulfide
-
 Spinacia oleracea L-cysteine + Cl-
-
 ?
4.4.1.9 L-cysteine + HCN
-
 Spinacia oleracea sulfide + L-3-cyanoalanine
-
 ?
4.4.1.9 O-acetyl-L-serine + sulfide
-
 Spinacia oleracea L-cysteine + acetate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.4.1.9 cyanoalanine synthase
-
 Spinacia oleracea

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.4.1.9 0.86
-
 cyanoalanine vs. O-acetyl-L-serine Spinacia oleracea
4.4.1.9 0.87
-
 KCN vs. O-acetyl-L-serine Spinacia oleracea
4.4.1.9 1.29
-
 homocysteine vs. O-acetyl-L-serine Spinacia oleracea
4.4.1.9 1.45
-
 sodium thiocyanate vs. O-acetyl-L-serine Spinacia oleracea
4.4.1.9 2.27
-
 chloroalanine vs. L-cysteine Spinacia oleracea
4.4.1.9 2.59
-
 KCN vs. chloroalanine Spinacia oleracea
4.4.1.9 5
-
 O-acetyl-L-serine vs. chloroalanine Spinacia oleracea
4.4.1.9 5.93
-
 cyanoalanine vs. chloroalanine Spinacia oleracea
4.4.1.9 9.04
-
 sodium thiocyanate vs. chloroalanine Spinacia oleracea
4.4.1.9 9.9
-
 homocysteine vs. chloroalanine Spinacia oleracea
4.4.1.9 10.1
-
 homocysteine vs. L-cysteine Spinacia oleracea
4.4.1.9 15.1
-
 sodium thiocyanate vs. L-cysteine Spinacia oleracea
4.4.1.9 30
-
 cyanoalanine vs. L-cysteine Spinacia oleracea