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Literature summary extracted from

  • Walters, M.P.; Conway, S.P.
    Cholesterol esterase activities in commercial pancreatic enzyme preparations and implications for use in pancreatic insufficient cystic fibrosis (2001), J. Clin. Pharm. Ther., 26, 425-431.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.13 3-hydroxy bile salt dependent on, both hydrolysis and synthesis Sus scrofa
3.1.1.13 sodium taurocholate dependent on, both hydrolysis and synthesis Sus scrofa

Application

EC Number Application Comment Organism
3.1.1.13 medicine pancreatic enzyme preparation is used in human pancreatic cystic fibrosis therapy Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.13 extracellular
-
 Sus scrofa
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.13 Sus scrofa
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.1.13 glycoprotein
-
 Sus scrofa

Reaction

EC Number Reaction Comment Organism Reaction ID
3.1.1.13 steryl ester + H2O = sterol + fatty acid a group of enzymes of broad specificity, acting on esters of sterols and long-chain fatty acids, that may also bring about the esterification of sterols. Activated by bile salts Sus scrofa
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.13 commercial preparation various commercial preparations from pancreas and pure enzyme Sus scrofa
-
3.1.1.13 pancreas
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.1.13 additional information
-
-
 Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.13 cholesterol ester + H2O hydrolysis level greatly exceeds the synthesis level, enzyme can simultaneously perform synthesis and hydrolysis reactions Sus scrofa cholesterol + fatty acid
-
 r
3.1.1.13 oleic acid + cholesterol
-
 Sus scrofa cholesteryl oleate
-
 r
3.1.1.13 oleic acid + retinol
-
 Sus scrofa retinyl oleate
-
 r
3.1.1.13 retinyl palmitate + H2O
-
 Sus scrofa retinol + palmitate
-
 r
3.1.1.13 tocopherol acetate + H2O
-
 Sus scrofa tocopherol + acetate
-
 r

Synonyms

EC Number Synonyms Comment Organism
3.1.1.13 bile salt-stimulated lipase
-
 Sus scrofa
3.1.1.13 cholesterol esterase
-
 Sus scrofa
3.1.1.13 pancreatic carboxyl ester hydrolase
-
 Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.13 5.5
-
 hydrolysis in presence of taurocholate Sus scrofa
3.1.1.13 5.8
-
 synthesis in presence of taurocholate Sus scrofa