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Literature summary extracted from
- Mechanism of chorismate synthase. Role of the two invariant histidine residues in the active site (2004), J. Biol. Chem., 279, 9451-9461.
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 4.2.3.5 | H106A | mutant enzyme with 20fold reduced activity | Neurospora crassa |
| 4.2.3.5 | H17A | mutant enzyme with 10fold reduced activity | Neurospora crassa |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.3.5 | diethyl dicarbonate | - |
Neurospora crassa |  |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.2.3.5 | 0.043 | - |
NADPH | FMN:NADPH oxidoreductase activity, wild-type enzyme | Neurospora crassa | |
| 4.2.3.5 | 0.11 | - |
NADPH | FMN:NADPH oxidoreductase activity, mutant enzyme H17A | Neurospora crassa | |
| 4.2.3.5 | 0.28 | - |
NADPH | FMN:NADPH oxidoreductase activity, mutant enzyme H106A | Neurospora crassa | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.3.5 | O5-(1-carboxyvinyl)-3-phosphoshikimate | Neurospora crassa | last step in shikimate pathway | chorismate + phosphate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.2.3.5 | Neurospora crassa | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.3.5 | FMN + NADPH | - |
Neurospora crassa | ? | - |
? | |
| 4.2.3.5 | additional information | the enzyme also shows FMN:NADPH oxidoreductase activity | Neurospora crassa | ? | - |
? | |
| 4.2.3.5 | O5-(1-carboxyvinyl)-3-phosphoshikimate | - |
Neurospora crassa | chorismate + phosphate | - |
? | |
| 4.2.3.5 | O5-(1-carboxyvinyl)-3-phosphoshikimate | last step in shikimate pathway | Neurospora crassa | chorismate + phosphate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.2.3.5 | CS | - |
Neurospora crassa |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.3.5 | FMNH2 | absolute requirement for FMNH2, which is not consumed during the reaction | Neurospora crassa | |
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Release 2023.1 (January 2023)
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