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Literature summary extracted from

  • Cordell, P.A.; Futers, T.S.; Grant, P.J.; Pease, R.J.
    The human hydroxyacylglutathione hydrolase (HAGH) gene encodes both cytosolic and mitochondrial forms of glyoxalase II (2004), J. Biol. Chem., 279, 28653-28661.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.2.6 DNA sequence determination and analysis of the single HAGH gene encoding both the cytosolic and mitochondrial isozymes, in vitro transcription, 2 splicing forms of mRNA Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.2.6 cytosol
-
Homo sapiens 5829
-
3.1.2.6 cytosol cytosolic isozyme Homo sapiens 5829
-
3.1.2.6 mitochondrial matrix mitochondrial isozyme is targeted directly to the mitochondrial matrix due to a mitochondrial targeting sequence Homo sapiens 5759
-
3.1.2.6 mitochondrion
-
Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.2.6 S-D-lactoylglutathione + H2O Homo sapiens
-
glutathione + D-lactate
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.6 Homo sapiens
-
HAGH gene encodes both cytosolic and mitochondrial forms of glyoxalase II
-
3.1.2.6 Homo sapiens Q16775 cytosolic and mitochondrial isozyme, both encoded by gene HAGH for hydroxyacylglutathione hydrolase
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.6 additional information enzyme shows broad substrate specificity with a preference for 2-hydoxy thiol esters Homo sapiens ?
-
?
3.1.2.6 S-D-lactoylglutathione + H2O
-
Homo sapiens glutathione + D-lactate
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.2.6 acetoacetylglutathione hydrolase
-
Homo sapiens
3.1.2.6 Germ cell specific protein
-
Homo sapiens
3.1.2.6 GLO II
-
Homo sapiens
3.1.2.6 glyoxalase II
-
Homo sapiens
3.1.2.6 HAGH
-
Homo sapiens
3.1.2.6 hydrolase, acetoacetylglutathione
-
Homo sapiens
3.1.2.6 hydrolase, hydroxyacylglutathione
-
Homo sapiens
3.1.2.6 More enzyme is a member of the zinc metallohydrolase family with a beta-lactamase fold Homo sapiens
3.1.2.6 Round spermatid protein RSP29
-
Homo sapiens
3.1.2.6 S-2-hydroxylacylglutathione hydrolase
-
Homo sapiens