Literature summary extracted from
Sinha, S.C.; Chaudhuri, B.N.; Burgner, J.W.; Yakovleva, G.; Davisson, V.J.; Smith, J.L.
Crystal structure of imidazole glycerol-phosphate dehydratase: Duplication of an unusual fold (2004), J. Biol. Chem., 279, 15491-15498.
Crystallization (Commentary)
EC Number |
Crystallization (Comment) |
Organism |
---|
4.2.1.19 |
trimeric form without Mn2+, hanging drop vapor diffusion method |
Cryptococcus neoformans |
Metals/Ions
EC Number |
Metals/Ions |
Comment |
Organism |
Structure |
---|
4.2.1.19 |
Mg2+ |
metalloprotein, transition metals induce aggregation and are required for catalysis, 1 equivalent of Mn2+ per subunit induces the formation of 24-mers from the trimeric enzyme |
Cryptococcus neoformans |
|
Natural Substrates/ Products (Substrates)
EC Number |
Natural Substrates |
Organism |
Comment (Nat. Sub.) |
Natural Products |
Comment (Nat. Pro.) |
Rev. |
Reac. |
---|
4.2.1.19 |
additional information |
Cryptococcus neoformans |
sixth step in histidine biosynthesis |
? |
- |
? |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
4.2.1.19 |
Cryptococcus neoformans |
P0CO22 |
- |
- |
Purification (Commentary)
EC Number |
Purification (Comment) |
Organism |
---|
4.2.1.19 |
- |
Cryptococcus neoformans |
Substrates and Products (Substrate)
EC Number |
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
---|
4.2.1.19 |
D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate |
removal of a non-acidic hydrogen atom in the dehydration reaction |
Cryptococcus neoformans |
3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O |
- |
? |
|
4.2.1.19 |
additional information |
sixth step in histidine biosynthesis |
Cryptococcus neoformans |
? |
- |
? |
|
Subunits
EC Number |
Subunits |
Comment |
Organism |
---|
4.2.1.19 |
multimer |
1 equivalent of Mn2+ per subunit induces the formation of 24-mers from the trimeric enzyme |
Cryptococcus neoformans |
4.2.1.19 |
trimer |
1 equivalent of Mn2+ per subunit induces the formation of 24-mers from the trimeric enzyme |
Cryptococcus neoformans |