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Literature summary extracted from

  • Duan, R.D.; Bergman, T.; Xu, N.; Wu, J.; Cheng, Y.; Duan, J.; Nelander, S.; Palmberg, C.; Nilsson, A.
    Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family (2003), J. Biol. Chem., 278, 38528-38536.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.12 expression in COS7 cells Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.4.12 60000
-
x * 60000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 sphingomyelin + H2O Homo sapiens
-
N-acylsphingosine + choline phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Homo sapiens Q6UWV6
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.4.12 additional information five potential glycosylation sites Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.4.12
-
Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 duodenum high mRNA levels Homo sapiens
-
3.1.4.12 ileum low mRNA levels Homo sapiens
-
3.1.4.12 jejunum high mRNA levels Homo sapiens
-
3.1.4.12 liver high mRNA levels Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 sphingomyelin + H2O
-
Homo sapiens N-acylsphingosine + choline phosphate
-
?

Subunits

EC Number Subunits Comment Organism
3.1.4.12 ? x * 60000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 alk-SMase
-
Homo sapiens
3.1.4.12 alkaline sphingomyelinase
-
Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.12 9
-
recombinant alk-SMase Homo sapiens