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Literature summary extracted from

  • Lookene, A.; Zhang, L.; Tougu, V.; Olivecrona, G.
    1,1'-bis(anilino)-4-,4'-bis(naphtalene)-8,8'-disulfonate acts as an inhibitor of lipoprotein lipase and competes for binding with apolipoprotein CII (2003), J. Biol. Chem., 278, 37183-37194.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.34 apoprotein C II
-
 Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.34 1,1'-bis(anilino)-4-,4'-bis(naphthalen)-8,8'-disulfonate 0.01-0.015 mM, almost complete inhibition of tributyrin and tripropionin hydrolysis, competes for binding with apoprotein CII, inhibition is prevented or restored by apoprotein CII Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.34 triacylglycerol + H2O Bos taurus
-
 diacylglycerol + a carboxylate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.34 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.34 milk
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.34 p-nitrophenyl butyrate + H2O
-
 Bos taurus p-nitrophenol + butanoate
-
 ?
3.1.1.34 triacetin + H2O
-
 Bos taurus acetate + diacetin
-
 ?
3.1.1.34 triacylglycerol + H2O
-
 Bos taurus diacylglycerol + a carboxylate
-
 ?
3.1.1.34 tributyrin + H2O
-
 Bos taurus butanoate + dibutyrin
-
 ?
3.1.1.34 tricaprylin + H2O
-
 Bos taurus capric acid + dicaprylin
-
 ?
3.1.1.34 triolein + H2O
-
 Bos taurus oleate + diolein
-
 ?
3.1.1.34 tripropionin + H2O
-
 Bos taurus propionate + dipropionin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.34 LPL
-
 Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.1.34 0.00004
-
 1,1'-bis(anilino)-4-,4'-bis(naphthalen)-8,8'-disulfonate 25°C, pH 8.5, hydrolysis of p-nitrophenyl butyrate Bos taurus
3.1.1.34 0.00028
-
 1,1'-bis(anilino)-4-,4'-bis(naphthalen)-8,8'-disulfonate 25°C, pH 8.5, hydrolysis of tripropionin Bos taurus
3.1.1.34 0.00038
-
 1,1'-bis(anilino)-4-,4'-bis(naphthalen)-8,8'-disulfonate 25°C, pH 8.5, hydrolysis of tributyrin Bos taurus
3.1.1.34 0.0017
-
 1,1'-bis(anilino)-4-,4'-bis(naphthalen)-8,8'-disulfonate 25°C, pH 8.5, hydrolysis of tricaprylin Bos taurus
3.1.1.34 0.0031
-
 1,1'-bis(anilino)-4-,4'-bis(naphthalen)-8,8'-disulfonate 25°C, pH 8.5, hydrolysis of triacetin Bos taurus
3.1.1.34 0.0047
-
 1,1'-bis(anilino)-4-,4'-bis(naphthalen)-8,8'-disulfonate 25°C, pH 8.5, hydrolysis of triolein Bos taurus