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Literature summary extracted from

  • Cilenti, L.; Lee, Y.; Hess, S.; Srinivasula, S.; Park, K.M.; Junqueira, D.; Davis, H.; Bonventre, J.V.; Alnemri, E.S.; Zervos, A.S.
    Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2 (2003), J. Biol. Chem., 278, 11489-11494.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.108
-
 Mammalia

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.108 ucf-101 78% inhibition at 0.02 mM, complete inhibition at 0.08 mM Mammalia
3.4.21.108 ucf-102 inhibits, but to a lesser extent than ucf-101 Mammalia
3.4.21.108 ucf-103 inhibits, but to a lesser extent than ucf-101 Mammalia
3.4.21.108 ucf-104 58% inhibition at 0.02 mM Mammalia

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.108 mitochondrion
-
 Mammalia 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.108 additional information Mammalia induces cell death in a caspase-dependent manner ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.108 Mammalia
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.108 alpha-casein + H2O
-
 Mammalia ?
-
 ?
3.4.21.108 beta-casein + H2O
-
 Mammalia ?
-
 ?
3.4.21.108 dephosphorylated casein + H2O
-
 Mammalia ?
-
 ?
3.4.21.108 additional information induces cell death in a caspase-dependent manner Mammalia ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.108 HtrA2/Omi
-
 Mammalia
3.4.21.108 S01.278 Merops ID Mammalia