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Literature summary extracted from

  • Verhagen, A.M.; Silke, J.; Ekert, P.G.; Pakusch, M.; Kaufmann, H.; Connolly, L.M.; Day, C.L.; Tikoo, A.; Burke, R.; Wrobel, C.; Moritz, R.L.; Simpson, R.J.; Vaux, D.L.
    HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins (2002), J. Biol. Chem., 277, 445-454.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.108
-
 Mammalia

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.108 A144G mutation reduces ability to promote cell death, weak interaction with XIAP Mammalia
3.4.21.108 A147I increased affinity for the BIR3 domain of XIAP Mammalia
3.4.21.108 S306A mutation reduces ability to promote cell death Mammalia
3.4.21.108 S306A/A144G complete loss of proapoptotic activity Mammalia

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.108 membrane
-
 Mammalia 16020
-
3.4.21.108 mitochondrion in response to UV irradiation the enzyme shifts into the cytosol Mammalia 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.108 35000
-
 calculated from nucleotide sequence Mammalia

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.108 additional information Mammalia role in apoptosis, mice with mutant HtrA2/Omi suffer from neurodegenerative disease due to progressive mitochondrial damage, mutant enzyme is proteolytically inactive but can bind to IAPs ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.108 Mammalia
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.108 proteolytic modification precursor protein is processed to yield an active protase Mammalia

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.108 beta-casein + H2O
-
 Mammalia ?
-
 ?
3.4.21.108 additional information role in apoptosis, mice with mutant HtrA2/Omi suffer from neurodegenerative disease due to progressive mitochondrial damage, mutant enzyme is proteolytically inactive but can bind to IAPs Mammalia ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.108 HtrA2/Omi
-
 Mammalia

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.108 37
-
 assay at Mammalia

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.108 8
-
 assay at Mammalia

pI Value

EC Number Organism Comment pI Value Maximum pI Value
3.4.21.108 Mammalia calculated from nucleotide sequence
-
 6.7