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Literature summary extracted from

  • Hernandez-Acosta, P.; Schmid, D.G.; Jung, G.; Culianez-Macia, F.A.; Kupke, T.
    Molecular characterization of the Arabidopsis thaliana flavoprotein AtHAL3a reveals the general reaction mechanism of 4'-phosphopantothenoylcysteine decarboxylases (2002), J. Biol. Chem., 277, 20490-20498.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.36 expressed in Escherichia coli BL21 (DE3) Arabidopsis thaliana

Protein Variants

EC Number Protein Variants Comment Organism
4.1.1.36 A174S site-directed mutagenesis Arabidopsis thaliana
4.1.1.36 A174V site-directed mutagenesis Arabidopsis thaliana
4.1.1.36 C175S site-directed mutagenesis Arabidopsis thaliana
4.1.1.36 D177N site-directed mutagenesis Arabidopsis thaliana
4.1.1.36 G179A site-directed mutagenesis Arabidopsis thaliana
4.1.1.36 R95Q site-directed mutagenesis Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.36 D-pantothenoylcysteine Arabidopsis thaliana pantothenoylaminoethenethiol is the intermediate in decarboxylation pantotheine + CO2
-
?
4.1.1.36 N-[(R)-4'-phosphopantothenoyl]-L-cysteine Arabidopsis thaliana key step in coenzyme A biosynthesis pantotheine 4'-phosphate + CO2
-
?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.36 Arabidopsis thaliana
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.36 recombinant enzyme Arabidopsis thaliana

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.36 D-pantothenoylcysteine pantothenoylaminoethenethiol is the intermediate in decarboxylation Arabidopsis thaliana pantotheine + CO2
-
?
4.1.1.36 N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
Arabidopsis thaliana pantotheine 4'-phosphate + CO2
-
?
4.1.1.36 N-[(R)-4'-phosphopantothenoyl]-L-cysteine key step in coenzyme A biosynthesis Arabidopsis thaliana pantotheine 4'-phosphate + CO2
-
?

Subunits

EC Number Subunits Comment Organism
4.1.1.36 trimer
-
Arabidopsis thaliana

Synonyms

EC Number Synonyms Comment Organism
4.1.1.36 AtHAL3a
-
Arabidopsis thaliana

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.36 flavin flavoprotein Arabidopsis thaliana