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Literature summary extracted from

  • Miclet, E.; Stoven, V.; Michels, P.A.M.; Opperdoes, F.R.; Lallemand, J.Y.; Duffieux, F.
    NMR spectroscopic analysis of the first two steps of the pentose-phosphate pathway elucidates the role of 6-phosphogluconolactonase (2001), J. Biol. Chem., 276, 34840-34846.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.31 expression in Escherichia coli Trypanosoma brucei
3.1.1.31 expression in Escherichia coli Homo sapiens
3.1.1.31 expression of lactonase domain Pf6PGL in Escherichia coli, low recovery of soluble Pf6PGL Plasmodium falciparum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.31 6-phospho-D-glucono-1,5-lactone + H2O Trypanosoma brucei
-
 6-phospho-D-gluconate
-
 ?
3.1.1.31 6-phospho-D-glucono-1,5-lactone + H2O Homo sapiens
-
 6-phospho-D-gluconate
-
 ?
3.1.1.31 6-phospho-D-glucono-1,5-lactone + H2O Plasmodium falciparum
-
 6-phospho-D-gluconate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.31 Homo sapiens O95336
-
-
3.1.1.31 Plasmodium falciparum Q27741 bifunctional enzyme having both glucose-6-phosphate dehydrogenase and 6-phosphogluconolactonase activity
-
3.1.1.31 Trypanosoma brucei Q9GRG6
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.31 recombinant 6PGL Trypanosoma brucei
3.1.1.31 recombinant 6PGL Homo sapiens
3.1.1.31 recombinant 6PGL Plasmodium falciparum

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.1.31 60
-
 recombinant 6PGL Plasmodium falciparum
3.1.1.31 180
-
 recombinant 6PGL Trypanosoma brucei
3.1.1.31 3330
-
 recombinant 6PGL Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.31 6-phospho-D-glucono-1,5-lactone + H2O
-
 Trypanosoma brucei 6-phospho-D-gluconate
-
 ?
3.1.1.31 6-phospho-D-glucono-1,5-lactone + H2O
-
 Homo sapiens 6-phospho-D-gluconate
-
 ?
3.1.1.31 6-phospho-D-glucono-1,5-lactone + H2O
-
 Plasmodium falciparum 6-phospho-D-gluconate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.31 6-phosphogluconolactonase
-
 Trypanosoma brucei
3.1.1.31 6-phosphogluconolactonase
-
 Homo sapiens
3.1.1.31 6-phosphogluconolactonase
-
 Plasmodium falciparum
3.1.1.31 6PGL
-
 Trypanosoma brucei
3.1.1.31 6PGL
-
 Homo sapiens
3.1.1.31 6PGL-G6PDH
-
 Plasmodium falciparum
3.1.1.31 Pf6PGL
-
 Plasmodium falciparum