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Literature summary extracted from

  • Chopin, V.; Salzet, M.; Baert, J.L.; Vandenbulcke, F.; Sautiere, P.E.; Kerckaert, J.P.; Malecha, J.
    Therostasin, a novel clotting factor Xa inhibitor from the rhynchobdellid leech, Theromyzon tessulatum (2000), J. Biol. Chem., 275, 32701-32707.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.6 therostasin highly specific, natural, tight-binding inhibitor, 5200fold purified from the rhynchobdellid leech Theromyzon tessulatum, DNA and amino acid sequence determination and analysis, protein of 8990 Da encoded by 825 bp, SwissProt accession number P82355, GenBank accession number AF239803, causes a 4fold increase in blood clotting velocity Mammalia

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.6 Mammalia
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.21.6 selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin scutelarin has similar specificity Mammalia
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.6 S2238 + H2O
-
 Mammalia ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.6 clotting factor Xa
-
 Mammalia
3.4.21.6 factor Xa
-
 Mammalia
3.4.21.6 additional information the enzyme belongs to the peptidase family S1, i.e. trypsin family Mammalia

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.6 22
-
 assay at room temperature Mammalia

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.6 8.4
-
 assay at Mammalia

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.21.6 0.000000034
-
 therostasin
-
 Mammalia