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Literature summary extracted from

  • Ro, H.S.; Wilson Miles, E.
    Catalytic mechanism of the tryptophan synthase alpha(2)beta(2) complex. Effects of pH, isotopic substitution, and allosteric ligands (1999), J. Biol. Chem., 274, 31189-31194.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.20 glycine competitive Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.20 additional information inhibition mechanism Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.20 oxindolyl-L-alanine competitive Salmonella enterica subsp. enterica serovar Typhimurium

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.2.1.20 additional information
-
 additional information kinetics, temperature-, and pH-dependence, and isotope effect at pH 7.0, not at pH 9.0, overview Salmonella enterica subsp. enterica serovar Typhimurium

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.20 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
4.2.1.20 L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O also catalyses the conversion of serine and indole into tryptophan and water, and of indoleglycerol phosphate into indole and glyceraldehyde phosphate (the latter reaction was listed formerly as EC 4.2.1.8), catalytic mechanism, allosteric ligand binding Salmonella enterica subsp. enterica serovar Typhimurium
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.20 1-(indol-3-yl)glycerol 3-phosphate + L-serine
-
 Salmonella enterica subsp. enterica serovar Typhimurium L-tryptophan + D-glyceraldehyde 3-phosphate
-
 ?
4.2.1.20 serine + indole
-
 Salmonella enterica subsp. enterica serovar Typhimurium tryptophan + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
4.2.1.20 tetramer alpha2beta2 complex Salmonella enterica subsp. enterica serovar Typhimurium

Cofactor

EC Number Cofactor Comment Organism Structure
4.2.1.20 pyridoxal 5'-phosphate dependent on Salmonella enterica subsp. enterica serovar Typhimurium

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.2.1.20 7.3
-
 glycine
-
 Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.20 7.3
-
 oxindolyl-L-alanine
-
 Salmonella enterica subsp. enterica serovar Typhimurium