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Literature summary extracted from

  • Ramos, I.; Downs, D.M.
    Anthranilate synthase can generate sufficient phosphoribosyl amine for thiamine synthesis in Salmonella enterica (2003), J. Bacteriol., 185, 5125-5132.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.4.2.18 P362L mutation in enzyme complex subunit TrpD, increased activity compared to the wild-type enzyme Salmonella enterica
4.1.3.27 P362L TrpD subunit, enzyme is able to generate phosphoribosyl amine from ammonia and phosphoribosyl diphosphate Salmonella enterica

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.2.18 Mg2+
-
 Salmonella enterica

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate Salmonella enterica generation of phosphoribosyl amine from 5-phospho-alpha-D-ribose 1-diphosphate is a step in thiamine biosynthesis N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
2.4.2.18 additional information Salmonella enterica connections between purine, thiamine, and tryptophan biosynthetic pathways, overview, the enzyme complex can substitute for PurF in formation of phosphoribosyl amine in vivo ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.18 Salmonella enterica
-
-
-
4.1.3.27 Salmonella enterica
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.18 ammonia + 5-phospho-alpha-D-ribose 1-diphosphate anthranilate synthase-phosphoribosyl transferase complex subunit TrpD in vitro Salmonella enterica phosphoribosyl amine + diphosphate
-
 ?
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate generation of phosphoribosyl amine from 5-phospho-alpha-D-ribose 1-diphosphate is a step in thiamine biosynthesis Salmonella enterica N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate reaction is catalyzed by the TrpD subunit of the anthranilate synthase-phosphoribosyl transferase complex Salmonella enterica N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
2.4.2.18 additional information connections between purine, thiamine, and tryptophan biosynthetic pathways, overview, the enzyme complex can substitute for PurF in formation of phosphoribosyl amine in vivo Salmonella enterica ?
-
 ?
4.1.3.27 NH3 + phosphoribosyl diphosphate mutant P362L Salmonella enterica phosphoribosyl amine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.18 anthranilate phosphoribosyl transferase
-
 Salmonella enterica
2.4.2.18 More enzyme is component II of the anthranilate synthase-phosphoribosyl transferase complex Salmonella enterica

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.18 7.6
-
 assay at, formation of N-(5-phospho-D-ribosyl)-anthranilate Salmonella enterica