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Literature summary extracted from

  • Fazzio, T.G.; Roth, J.R.
    Evidence that the CysG protein catalyzes the first reaction specific to B12 synthesis in Salmonella typhimurium, insertion of cobalt (1996), J. Bacteriol., 178, 6952-6959.
    View publication on PubMedView publication on EuropePMC

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.3.1.76 Co2+ enzyme catalyzes cobalt insertion leading to B12 synthesis Salmonella enterica subsp. enterica serovar Typhimurium
1.3.1.76 Fe2+ enzyme catalyzes iron insertion leading to siroheme synthesis Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.76 precorrin-2 + NAD+ Salmonella enterica subsp. enterica serovar Typhimurium precorrin-2 is the precursor of both siroheme and B12, first reaction specific to B12 synthesis, second of three steps leading to formation of siroheme from uroporphyrinogen III sirohydrochlorin + NADH + H+
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Organism

EC Number Organism UniProt Comment Textmining
1.3.1.76 Salmonella enterica subsp. enterica serovar Typhimurium
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-
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.76 precorrin-2 + NAD+
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Salmonella enterica subsp. enterica serovar Typhimurium sirohydrochlorin + NADH + H+
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?
1.3.1.76 precorrin-2 + NAD+ precorrin-2 is the precursor of both siroheme and B12, first reaction specific to B12 synthesis, second of three steps leading to formation of siroheme from uroporphyrinogen III Salmonella enterica subsp. enterica serovar Typhimurium sirohydrochlorin + NADH + H+
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?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.76 CysG
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Salmonella enterica subsp. enterica serovar Typhimurium
1.3.1.76 CysG enzyme
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Salmonella enterica subsp. enterica serovar Typhimurium