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Literature summary extracted from

  • Yang, Q.H.; Church-Hajduk, R.; Ren, J.; Newton, M.L.; Du, C.
    Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis (2003), Genes Dev., 17, 1487-1496.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.108
-
 Mammalia

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.108 additional information Mammalia promotes apoptosis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.108 Mammalia
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.108
-
 Mammalia

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.108 alpha-casein + H2O
-
 Mammalia ?
-
 ?
3.4.21.108 beta-casein + H2O
-
 Mammalia ?
-
 ?
3.4.21.108 glycprotein alpha1 acid + H2O
-
 Mammalia ?
-
 ?
3.4.21.108 hyaluronidase + H2O
-
 Mammalia ?
-
 ?
3.4.21.108 inhibitor of apoptosis + H2O enzyme cleaves various IAPs Mammalia ?
-
 ?
3.4.21.108 Livin alpha + H2O
-
 Mammalia ?
-
 ?
3.4.21.108 Livin beta
-
 Mammalia ?
-
 ?
3.4.21.108 additional information promotes apoptosis Mammalia ?
-
 ?
3.4.21.108 protein cIAP1 + H2O best substrate, preferred cleavage sites are after Thr4, Asn133 and Leu161 Mammalia ?
-
 ?
3.4.21.108 protein cIAP2 + H2O
-
 Mammalia ?
-
 ?
3.4.21.108 protein DIAP1 + H2O
-
 Mammalia ?
-
 ?
3.4.21.108 protein XIAP + H2O
-
 Mammalia ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.108 HtrA2/Omi
-
 Mammalia

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.108 7.4
-
 assay at Mammalia