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Literature summary extracted from
- Sphingomyelinases: enzymology and membrane activity (2002), FEBS Lett., 531, 38-46.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.12 | bile salt | required for activity | Rattus norvegicus |  |
| 3.1.4.12 | phosphatidylserine | required for activity | Rattus norvegicus | |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.12 | glutathione | - |
Bos taurus | |
| 3.1.4.12 | glutathione | 3 mM, 95% inhibition | Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.4.12 | membrane | - |
Rattus norvegicus | 16020 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.12 | Mg2+ | required for activity | Rattus norvegicus | |
| 3.1.4.12 | Mg2+ | required for activity | Bos taurus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.1.4.12 | 46000 | - |
x * 97000 + x * 46000, the 46000 Da subunit may also be a degradation product | Bos taurus |
| 3.1.4.12 | 97000 | - |
x * 97000 + x * 46000, the 46000 Da subunit may also be a degradation product | Bos taurus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.12 | sphingomyelin + H2O | Rattus norvegicus | - |
N-acylsphingosine + choline phosphate | - |
? | |
| 3.1.4.12 | sphingomyelin + H2O | Bos taurus | - |
N-acylsphingosine + choline phosphate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.4.12 | Bos taurus | - |
- |
- |
| 3.1.4.12 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.4.12 | - |
Rattus norvegicus |
| 3.1.4.12 | - |
Bos taurus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.4.12 | brain | - |
Rattus norvegicus | - |
| 3.1.4.12 | brain | - |
Bos taurus | - |
| 3.1.4.12 | intestine | exclusively expressed in intestine, lack of bSMase may be related to colon carcinogenesis | Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.12 | sphingomyelin + H2O | - |
Rattus norvegicus | N-acylsphingosine + choline phosphate | - |
? | |
| 3.1.4.12 | sphingomyelin + H2O | - |
Bos taurus | N-acylsphingosine + choline phosphate | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.1.4.12 | ? | x * 97000 + x * 46000, the 46000 Da subunit may also be a degradation product | Bos taurus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.4.12 | alkaline sphingomyelinase | - |
Rattus norvegicus |
| 3.1.4.12 | bSMase | - |
Rattus norvegicus |
| 3.1.4.12 | neutral sphingomyelinase | - |
Rattus norvegicus |
| 3.1.4.12 | neutral sphingomyelinase | - |
Bos taurus |
| 3.1.4.12 | nSMase | - |
Rattus norvegicus |
| 3.1.4.12 | nSMase | - |
Bos taurus |
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Release 2023.1 (January 2023)
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