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Literature summary extracted from

  • Kowluru, A.
    Adenine and guanine nucleotide-specific succinyl-CoA synthetases in the clonal beta-cell mitochondria: implications in the beta-cell high-energy phosphate metabolism in relation to physiological insulin secretion (2001), Diabetologia, 44, 89-94.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.2.1.4 mitochondrion
-
 Rattus norvegicus 5739
-
6.2.1.5 mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.4 GDP + phosphate + succinyl-CoA Rattus norvegicus GTP generated by the activation of succinyl-CoA synthetase could promote key functional roles in the mitochondrial metabolism leading to insulin secretion GTP + succinate + CoA
-
 ?
6.2.1.5 ADP + phosphate + succinyl-CoA Rattus norvegicus generation of ATP is critical for the beta-cell mitochondrial metabolism ATP + succinate + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.4 Rattus norvegicus
-
-
-
6.2.1.5 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
6.2.1.4 phosphoprotein the alpha-subunit of succinyl-CoA synthetase undergoes autophosphorylation at a histidine residue. Coprovision of exogenous succinate and CoA results in pronounced dephosphorylation of the phosphorylated alpha-subunit of succinyl-CoA synthetase Rattus norvegicus
6.2.1.5 phosphoprotein the alpha-subunit of succinyl-CoA synthetase undergoes autophosphorylation at a histidine residue. Coprovision of exogenous succinate and CoA results in pronounced dephosphorylation of the phosphorylated alpha-subunit of succinyl-CoA synthetase Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.4 HIT-T15 cell two distinct ATP-specific and GTP-specific succinyl-CoA synthetases Rattus norvegicus
-
6.2.1.4 INS-1 cell two distinct ATP-specific and GTP-specific succinyl-CoA synthetases Rattus norvegicus
-
6.2.1.5 HIT-T15 cell two distinct ATP-specific and GTP-specific succinyl-CoA synthetases Rattus norvegicus
-
6.2.1.5 INS-1 cell two distinct ATP-specific and GTP-specific succinyl-CoA synthetases Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.4 GDP + phosphate + succinyl-CoA GTP generated by the activation of succinyl-CoA synthetase could promote key functional roles in the mitochondrial metabolism leading to insulin secretion Rattus norvegicus GTP + succinate + CoA
-
 ?
6.2.1.4 GTP + succinate + CoA
-
 Rattus norvegicus GDP + phosphate + succinyl-CoA
-
 ?
6.2.1.5 ADP + phosphate + succinyl-CoA generation of ATP is critical for the beta-cell mitochondrial metabolism Rattus norvegicus ATP + succinate + CoA
-
 ?
6.2.1.5 ATP + succinate + CoA
-
 Rattus norvegicus ADP + phosphate + succinyl-CoA
-
 ?