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Literature summary extracted from

  • El-Maghrabi, M.R.; Noto, F.; Wu, N.; Manes, N.
    6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: suiting structure to need, in a family of tissue-specific enzymes (2001), Curr. Opin. Clin. Nutr. Metab. Care, 4, 411-418.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.3.46 medicine enzyme regulation by hormones, overview Mammalia

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.46 Mammalia
-
 bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.3.46 phosphoprotein amino-terminal phosphorylation site of liver isoform, carboxy-terminal phosphorylation site of heart and brain isoform, regulation by phosphorylation, overview Mammalia

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.46 brain tissue-specific isoform, overview Mammalia
-
3.1.3.46 heart tissue-specific isoform, overview Mammalia
-
3.1.3.46 liver tissue-specific isoform, amino-terminal phosphorylation site, overview Mammalia
-
3.1.3.46 muscle tissue-specific isoform, overview Mammalia
-
3.1.3.46 testis tissue-specific isoform, overview Mammalia
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Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.3.46 additional information
-
 comparison of kinetic properties of isoforms, enzyme regulation by hormones, overview Mammalia

Subunits

EC Number Subunits Comment Organism
3.1.3.46 homodimer 2 * 48000-58000, overview Mammalia