Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Hodgkin, M.N.; Masson, M.R.; Powner, D.; Saqib, K.M.; Ponting, C.P.; Wakelam, M.J.O.
    Phospholipase D regulation and localization is dependent upon a phosphatidylinositol 4,5-bisphosphate-specific PH domain (2000), Curr. Biol., 10, 43-46.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.4 phosphatidylinositol
-
 Homo sapiens
3.1.4.4 phosphatidylinositol-3,4,5-trisphosphate effective activator Homo sapiens
3.1.4.4 phosphatidylinositol-3,4-diphosphate very effective activator Homo sapiens
3.1.4.4 phosphatidylinositol-3,5-diphosphate effective activator Homo sapiens
3.1.4.4 phosphatidylinositol-3-phosphate effective activator Homo sapiens
3.1.4.4 phosphatidylinositol-4,5-diphosphate very effective activator Homo sapiens
3.1.4.4 phosphatidylserine
-
 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.4 F250S dramatic reduction of enzyme activity Homo sapiens
3.1.4.4 K228R dramatic reduction of enzyme activity Homo sapiens
3.1.4.4 additional information deletion of pleckstrin homology domain, disruption of normal cellular localization, loss of enzyme activity Homo sapiens
3.1.4.4 S230F dramatic reduction of enzyme activity Homo sapiens
3.1.4.4 W253C almost complete loss of enzyme activity Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.4 Homo sapiens
-
 isozymes PLD1, PLD2
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.4 phosphatidylcholine + H2O
-
 Homo sapiens choline + phosphatidate
-
 ?