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Literature summary extracted from

  • Ishigure, K.; Shimomura, Y.; Murakami, T.; Kaneko, T.; Takeda, S.; Inoue, S.; Nomoto, S.; Koshikawa, K.; Nonami, T.; Nakao, A.
    Human liver disease decreases methacrylyl-CoA hydratase and beta-hydroxyisobutyryl-CoA hydrolase activities in valine catabolism (2001), Clin. Chim. Acta, 312, 115-121.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.2.4 3-hydroxy-2-methylpropanoyl-CoA + H2O Homo sapiens key enzyme in valine metabolism regulating the toxic concentration of methacrylyl-coenzyme A, human liver disease decreases the enzyme activity in vivo CoA + 3-hydroxy-2-methylpropanoate
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.4 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.2.4 hepatoma cell 46% reduced activity compared to healthy cells Homo sapiens
-
3.1.2.4 liver 36% reduced activity in livers with chronic hepatitis and cirrhosis compared to healthy livers Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.2.4 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.4 3-hydroxy-2-methylpropanoyl-CoA + H2O
-
 Homo sapiens CoA + 3-hydroxy-2-methylpropanoate
-
 ir
3.1.2.4 3-hydroxy-2-methylpropanoyl-CoA + H2O key enzyme in valine metabolism regulating the toxic concentration of methacrylyl-coenzyme A, human liver disease decreases the enzyme activity in vivo Homo sapiens CoA + 3-hydroxy-2-methylpropanoate
-
 ir

Synonyms

EC Number Synonyms Comment Organism
3.1.2.4 beta-hydroxyisobutyryl-coenzyme A hydrolase
-
 Homo sapiens
3.1.2.4 HIB-CoA hydrolase
-
 Homo sapiens