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Literature summary extracted from

  • Saldanha, S.A.; Birch, L.M.; Webb, M.E.; Nabbs, B.K.; von Delft, F.; Smith, A.G.; Abell, C.
    Identification of Tyr58 as the proton donor in the aspartate-alpha-decarboxylase reaction (2001), Chem. Commun. (Camb.), 2001, 1760-1761.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.11 panD gene overexpression Escherichia coli

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.1.1.11
-
 Escherichia coli

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.11 14000
-
 4 * 14000 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.11 L-aspartate Escherichia coli involved in the biosynthesis of pantothenate beta-alanine + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.11 Escherichia coli
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
4.1.1.11 proteolytic modification an integral pyruvoyl group is formed by an autocatalytic posttranslational modification which cleaves the Gly-24/Ser-25 bond and converts Ser-25 into the pyruvoyl group Escherichia coli

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.11 recombinant enzyme Escherichia coli

Reaction

EC Number Reaction Comment Organism Reaction ID
4.1.1.11 L-aspartate = beta-alanine + CO2 detailed catalytic mechanism Escherichia coli
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.11 L-aspartate reaction occurs with retention of configuration, Tyr58 acts as proton donor in the decarboxylation mechanism, the active sites are between subunits, mechanism involves formation of an imine between the amino group of aspartate and an integral pyruvoyl group formed by an autocatalytic posttranslational modification Escherichia coli beta-alanine + CO2
-
 ?
4.1.1.11 L-aspartate involved in the biosynthesis of pantothenate Escherichia coli beta-alanine + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.11 tetramer 4 * 14000 Escherichia coli

Synonyms

EC Number Synonyms Comment Organism
4.1.1.11 ADC
-
 Escherichia coli

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.1.1.11 25
-
 assay at Escherichia coli