BRENDA - Enzyme Database

Lysophospholipase D and its role in LPA production

Xie, Y.; Meier, K.E.; Cell. Signal. 16, 975-981 (2004)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
3.1.4.39
Co2+
extracellular enzyme
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.4.39
1,10-phenanthroline
extracellular enzyme
Homo sapiens
3.1.4.39
ATP
extracellular enzyme
Homo sapiens
3.1.4.39
Cu2+
the inhibition of extracellular enzyme can be prevented by 2,6-di-tert-butyl-4-hydroxy-methylphenol
Rattus norvegicus
3.1.4.39
EDTA
extracellular enzyme
Homo sapiens
3.1.4.39
EDTA
inhibition of extracellular enzyme
Rattus norvegicus
3.1.4.39
p-hydroxymercuribenzoate
the inhibition of the microsomal enzyme can be prevented by glutathione and dithiothreitol
Rattus norvegicus
3.1.4.39
serine esterase inhibitors
inhibition of extracellular enzyme
Rattus norvegicus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.4.39
extracellular
-
Rattus norvegicus
-
-
3.1.4.39
extracellular
-
Homo sapiens
-
-
3.1.4.39
microsome
-
Rattus norvegicus
-
-
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
3.1.4.39
Ca2+
-
Oryctolagus cuniculus
3.1.4.39
Ca2+
microsomal enzyme
Rattus norvegicus
3.1.4.39
Co2+
extracellular enzyme
Rattus norvegicus
3.1.4.39
Mg2+
low effect in rabbit kidney
Oryctolagus cuniculus
3.1.4.39
Mg2+
microsomal enzyme
Rattus norvegicus
3.1.4.39
Mn2+
extracellular enzyme
Rattus norvegicus
3.1.4.39
Ni2+
extracellular enzyme
Rattus norvegicus
3.1.4.39
Zn2+
extracellular enzyme
Rattus norvegicus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.4.39
additional information
Rattus norvegicus
the product lysophosphatidic acid mediates multiple biological functions
?
-
Rattus norvegicus
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.4.39
Bos taurus
-
-
-
3.1.4.39
Homo sapiens
-
-
-
3.1.4.39
Oryctolagus cuniculus
-
-
-
3.1.4.39
Rattus norvegicus
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
3.1.4.39
-
Homo sapiens
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.4.39
adipose tissue
medium of cultured adipocytes
Homo sapiens
-
3.1.4.39
brain
-
Rattus norvegicus
-
3.1.4.39
epithelial cell
-
Rattus norvegicus
-
3.1.4.39
gastric mucosa
-
Rattus norvegicus
-
3.1.4.39
kidney
-
Oryctolagus cuniculus
-
3.1.4.39
liver
-
Rattus norvegicus
-
3.1.4.39
plasma
-
Oryctolagus cuniculus
-
3.1.4.39
plasma
-
Rattus norvegicus
-
3.1.4.39
plasma
-
Homo sapiens
-
3.1.4.39
testis
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.4.39
1-alkyl-sn-glycero-3-phosphocholine + H2O
-
650814
Rattus norvegicus
1-alkyl-sn-glycero-3-phosphate + choline
-
650814
Rattus norvegicus
?
3.1.4.39
1-O-alkyl-2-lyso-sn-glycero-3-phosphoethanolamine + H2O
the microsomal enzyme
650814
Rattus norvegicus
1-O-alkyl-2-lyso-sn-glycero-3-phosphate + ethanolamine
the microsomal enzyme
650814
Rattus norvegicus
?
3.1.4.39
additional information
the microsomal enzymes prefer alkyl-lysophospholipids, the extracellular enzyme prefer acyl-phospholipids, but can use alkyl-lysophospholipids
650814
Rattus norvegicus
?
-
650814
Rattus norvegicus
?
3.1.4.39
additional information
the plasma enzyme hydrolyzes acyl-, alkyl- and alkenyl-lysophophatidylcholines
650814
Homo sapiens
?
-
650814
Homo sapiens
?
3.1.4.39
additional information
the product lysophosphatidic acid mediates multiple biological functions
650814
Rattus norvegicus
?
-
650814
Rattus norvegicus
?
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
3.1.4.39
Co2+
extracellular enzyme
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.4.39
1,10-phenanthroline
extracellular enzyme
Homo sapiens
3.1.4.39
ATP
extracellular enzyme
Homo sapiens
3.1.4.39
Cu2+
the inhibition of extracellular enzyme can be prevented by 2,6-di-tert-butyl-4-hydroxy-methylphenol
Rattus norvegicus
3.1.4.39
EDTA
extracellular enzyme
Homo sapiens
3.1.4.39
EDTA
inhibition of extracellular enzyme
Rattus norvegicus
3.1.4.39
p-hydroxymercuribenzoate
the inhibition of the microsomal enzyme can be prevented by glutathione and dithiothreitol
Rattus norvegicus
3.1.4.39
serine esterase inhibitors
inhibition of extracellular enzyme
Rattus norvegicus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.4.39
extracellular
-
Rattus norvegicus
-
-
3.1.4.39
extracellular
-
Homo sapiens
-
-
3.1.4.39
microsome
-
Rattus norvegicus
-
-
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
3.1.4.39
Ca2+
-
Oryctolagus cuniculus
3.1.4.39
Ca2+
microsomal enzyme
Rattus norvegicus
3.1.4.39
Co2+
extracellular enzyme
Rattus norvegicus
3.1.4.39
Mg2+
low effect in rabbit kidney
Oryctolagus cuniculus
3.1.4.39
Mg2+
microsomal enzyme
Rattus norvegicus
3.1.4.39
Mn2+
extracellular enzyme
Rattus norvegicus
3.1.4.39
Ni2+
extracellular enzyme
Rattus norvegicus
3.1.4.39
Zn2+
extracellular enzyme
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.4.39
additional information
Rattus norvegicus
the product lysophosphatidic acid mediates multiple biological functions
?
-
Rattus norvegicus
?
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
3.1.4.39
-
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.4.39
adipose tissue
medium of cultured adipocytes
Homo sapiens
-
3.1.4.39
brain
-
Rattus norvegicus
-
3.1.4.39
epithelial cell
-
Rattus norvegicus
-
3.1.4.39
gastric mucosa
-
Rattus norvegicus
-
3.1.4.39
kidney
-
Oryctolagus cuniculus
-
3.1.4.39
liver
-
Rattus norvegicus
-
3.1.4.39
plasma
-
Oryctolagus cuniculus
-
3.1.4.39
plasma
-
Rattus norvegicus
-
3.1.4.39
plasma
-
Homo sapiens
-
3.1.4.39
testis
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.4.39
1-alkyl-sn-glycero-3-phosphocholine + H2O
-
650814
Rattus norvegicus
1-alkyl-sn-glycero-3-phosphate + choline
-
650814
Rattus norvegicus
?
3.1.4.39
1-O-alkyl-2-lyso-sn-glycero-3-phosphoethanolamine + H2O
the microsomal enzyme
650814
Rattus norvegicus
1-O-alkyl-2-lyso-sn-glycero-3-phosphate + ethanolamine
the microsomal enzyme
650814
Rattus norvegicus
?
3.1.4.39
additional information
the microsomal enzymes prefer alkyl-lysophospholipids, the extracellular enzyme prefer acyl-phospholipids, but can use alkyl-lysophospholipids
650814
Rattus norvegicus
?
-
650814
Rattus norvegicus
?
3.1.4.39
additional information
the plasma enzyme hydrolyzes acyl-, alkyl- and alkenyl-lysophophatidylcholines
650814
Homo sapiens
?
-
650814
Homo sapiens
?
3.1.4.39
additional information
the product lysophosphatidic acid mediates multiple biological functions
650814
Rattus norvegicus
?
-
650814
Rattus norvegicus
?