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Literature summary extracted from

  • Raugei, G.; Ramponi, G.; Chiarugi, P.
    Low molecular weight protein tyrosine phosphatases: small, but smart (2002), Cell. Mol. Life Sci., 59, 941-949.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.3.48 additional information activation of enzyme after treatment with platelet derived growth factor, overview Mammalia

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.48 H2O2 inactivation, phosphate protects, mechanism, overview Homo sapiens
3.1.3.48 NO inactivation, phosphate protects Homo sapiens
3.1.3.48 phosphate competitive Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.48 cytoskeleton associated to Mammalia 5856
-
3.1.3.48 cytosol
-
 Mammalia 5829
-
3.1.3.48 membrane associated to plasma membrane Mammalia 16020
-
3.1.3.48 additional information overview Mammalia
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.48 18000
-
 x * 18000, all known members of enzyme subfamily, overview Mammalia

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.48 additional information Mammalia possible specific substrate is p190Rho-GAP ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.48 Homo sapiens
-
 two isozymes
-
3.1.3.48 Mammalia
-
 low molecular weight enzyme subfamily, overview
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.3.48 phosphoprotein regulation of enzyme activity by phosphorylation at T132, physiological effects, overview Mammalia

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.3.48 additional information
-
 regulation of enzyme by redox mechanism, overview Mammalia
3.1.3.48 additional information
-
 regulation of enzyme by redox mechanism, overview Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.48 additional information possible specific substrate is p190Rho-GAP Mammalia ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.3.48 ? x * 18000, all known members of enzyme subfamily, overview Mammalia
3.1.3.48 additional information three-dimensional structure model Mammalia

Synonyms

EC Number Synonyms Comment Organism
3.1.3.48 LMW-PTP
-
 Mammalia