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Literature summary extracted from

  • Morsczeck, C.; Berger, S.; Plum, G.
    The macrophage-induced gene (mig) of Mycobacterium avium encodes a medium-chain acyl-coenzyme A synthetase (2001), Biochim. Biophys. Acta, 1521, 59-65.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.2.1.2 a plasmid with a His-tagged fusion protein is constructed for expression in Escherichia coli Mycobacterium avium

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.2.1.2 2-hydroxydodecanoic acid
-
 Mycobacterium avium

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.2.1.2 0.02
-
 dodecanoate
-
 Mycobacterium avium
6.2.1.2 0.036
-
 ATP
-
 Mycobacterium avium
6.2.1.2 0.045
-
 CoA
-
 Mycobacterium avium
6.2.1.2 0.285
-
 Octanoate
-
 Mycobacterium avium
6.2.1.2 1.775
-
 Decanoate
-
 Mycobacterium avium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.2 additional information Mycobacterium avium the enzyme is involved in the metabolism of fatty acid during mycobacterial survival in macrophages ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.2 Mycobacterium avium
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.2.1.2
-
 Mycobacterium avium

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.2 ATP + 2-aminobenzoate + CoA 1.4% of the activity with dodecanoate Mycobacterium avium AMP + diphosphate + 2-aminobenzoyl-CoA
-
 ?
6.2.1.2 ATP + arachidonic acid + CoA 5.2% of the activity with dodecanoate Mycobacterium avium AMP + diphosphate + arachidonoyl-CoA
-
 ?
6.2.1.2 ATP + benzoate + CoA 2.3% of the activity with dodecanoate Mycobacterium avium AMP + diphosphate + benzoyl-CoA
-
 ?
6.2.1.2 ATP + decanoate + CoA substrate with the highest activity Mycobacterium avium AMP + diphosphate + decanoyl-CoA
-
 ?
6.2.1.2 ATP + dodecanoate + CoA 31% of the activity with dodecanoate Mycobacterium avium AMP + diphosphate + dodecanoyl-CoA
-
 ?
6.2.1.2 ATP + heptanoate + CoA 34% of the activity with dodecanoate Mycobacterium avium AMP + diphosphate + heptanoyl-CoA
-
 ?
6.2.1.2 ATP + hexanoate + CoA 35% of the activity with dodecanoate Mycobacterium avium AMP + diphosphate + hexanoyl-CoA
-
 ?
6.2.1.2 ATP + linolenic acid + CoA 8.3% of the activity with dodecanoate Mycobacterium avium AMP + diphosphate + linolenoyl-CoA
-
 ?
6.2.1.2 ATP + m-hydroxybenzoate + CoA 0.8% of the activity with dodecanoate Mycobacterium avium AMP + diphosphate + m-hydroxybenzoyl-CoA
-
 ?
6.2.1.2 ATP + octanoate + CoA 31% of the activity with dodecanoate Mycobacterium avium AMP + diphosphate + octanoyl-CoA
-
 ?
6.2.1.2 ATP + pentanoate + CoA 1.6% of the activity with dodecanoate Mycobacterium avium AMP + diphosphate + pentanoyl-CoA
-
 ?
6.2.1.2 ATP + tetradecanoate + CoA 3.9% of the activity with dodecanoate Mycobacterium avium AMP + diphosphate + tetradecanoyl-CoA
-
 ?
6.2.1.2 ATP + tridecanoate + CoA 15% of the activity with dodecanoate Mycobacterium avium AMP + diphosphate + tridecanoyl-CoA
-
 ?
6.2.1.2 additional information the enzyme is involved in the metabolism of fatty acid during mycobacterial survival in macrophages Mycobacterium avium ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.2.1.2 Mig protein
-
 Mycobacterium avium