EC Number | Crystallization (Comment) | Organism |
---|---|---|
3.1.1.7 | complex with rivastigmine or (-)-S-3-[1-(dimethylamino)ethyl]phenol, hanging drop vapor diffusion method | Tetronarce californica |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.1.7 | (-)-S-3-[1-(dimethylamino)ethyl]phenol | competitive reversible inhibitor | Tetronarce californica | |
3.1.1.7 | rivastigmine | trade name: Exelon, carbamylates the enzyme, enzyme reactivates spontaneous at a slow rate | Drosophila melanogaster | |
3.1.1.7 | rivastigmine | trade name: Exelon, carbamylates the enzyme, enzyme reactivates spontaneously at a slow rate | Homo sapiens | |
3.1.1.7 | rivastigmine | trade name: Exelon, carbamylates the enzyme, 10% spontaneous reactivation after 48 h | Tetronarce californica | |
3.1.1.7 | SDZ 212-712 | optical isomer of rivastigmine | Drosophila melanogaster | |
3.1.1.8 | rivastigmine | trade name: Exelon, carbamylates the enzyme | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.1.7 | Drosophila melanogaster | - |
- |
- |
3.1.1.7 | Homo sapiens | - |
- |
- |
3.1.1.7 | Tetronarce californica | P04058 | - |
- |
3.1.1.8 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.7 | acetylthiocholine + H2O | - |
Drosophila melanogaster | thiocholine + acetate | - |
? | |
3.1.1.7 | acetylthiocholine + H2O | - |
Homo sapiens | thiocholine + acetate | - |
? | |
3.1.1.7 | acetylthiocholine + H2O | - |
Tetronarce californica | thiocholine + acetate | - |
? | |
3.1.1.8 | butyrylthiocholine + H2O | - |
Homo sapiens | thiocholine + butyrate | - |
? |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.1.1.7 | 0.0005 | - |
(-)-S-3-[1-(dimethylamino)ethyl]phenol | pH 7.5, 25°C | Tetronarce californica |