Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Dvir, H.; Jiang, H.L.; Wong, D.M.; Harel, M.; Chetrit, M.; He, X.C.; Jin, G.Y.; Yu, G.L.; Tang, X.C.; Silman, I.; Bai, D.L.; Sussman, J.L.
    X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: Structural evidence for an active site rearrangement (2002), Biochemistry, 41, 10810-10818.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.1.1.7 complexed with (-)-huperzine B and (+)-huperzine A Tetronarce californica

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.7 (+)-huperzine A synthetic enantiomer of the anti-Alzheimer drug (-)-huperzine A and of its natural homologue (-)-huperzine B, interacts with the anionic subsite of the active site Tetronarce californica
3.1.1.7 (-)-huperzine A anti-Alzheimer drug Tetronarce californica
3.1.1.7 (-)-huperzine B
-
Tetronarce californica

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Tetronarce californica P04058
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.7 acetylcholine + H2O
-
Tetronarce californica choline + acetate
-
?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.1.7 0.175
-
(-)-huperzine A pH 7, 25°C Tetronarce californica
3.1.1.7 0.334
-
(-)-huperzine B pH 7, 25°C Tetronarce californica
3.1.1.7 4.3
-
(+)-huperzine A pH 7, 25°C Tetronarce californica