EC Number | Cloned (Comment) | Organism |
---|---|---|
6.3.2.1 | expression in Escherichia coli | Mycobacterium tuberculosis |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
6.3.2.1 | pantothenate | product inhibition | Mycobacterium tuberculosis |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
6.3.2.1 | 0.13 | - |
D-pantoate | 25°C, pH 7.8 | Mycobacterium tuberculosis | |
6.3.2.1 | 0.8 | - |
beta-Alanine | 25°C, pH 7.8 | Mycobacterium tuberculosis | |
6.3.2.1 | 2.6 | - |
ATP | 25°C, pH 7.8 | Mycobacterium tuberculosis |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
6.3.2.1 | Co2+ | maximal activity at 10 mM, slight activation | Mycobacterium tuberculosis | |
6.3.2.1 | Mg2+ | maximal activity at 10 mM, very strong activation | Mycobacterium tuberculosis | |
6.3.2.1 | Mn2+ | maximal activity at 10 mM, very strong activation | Mycobacterium tuberculosis | |
6.3.2.1 | Ni2+ | maximal activity at approx. 3 mM, slight activation | Mycobacterium tuberculosis |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
6.3.2.1 | 32677 | - |
2 * 32677, deduced from nucleotide sequence | Mycobacterium tuberculosis |
6.3.2.1 | 33000 | - |
2 * 33000, SDS-PAGE | Mycobacterium tuberculosis |
6.3.2.1 | 65000 | - |
gel filtration | Mycobacterium tuberculosis |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.3.2.1 | ATP + (R)-pantoate + beta-alanine | Mycobacterium tuberculosis | last step in pantothenate biosynthesis pathway | AMP + diphosphate + (R)-pantothenate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
6.3.2.1 | Mycobacterium tuberculosis | - |
PanC is essential for growth | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
6.3.2.1 | recombinant PanC | Mycobacterium tuberculosis |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.3.2.1 | ATP + (R)-pantoate + beta-alanine | - |
Mycobacterium tuberculosis | AMP + diphosphate + (R)-pantothenate | - |
? | |
6.3.2.1 | ATP + (R)-pantoate + beta-alanine | last step in pantothenate biosynthesis pathway | Mycobacterium tuberculosis | AMP + diphosphate + (R)-pantothenate | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
6.3.2.1 | dimer | 2 * 33000, SDS-PAGE | Mycobacterium tuberculosis |
6.3.2.1 | dimer | 2 * 32677, deduced from nucleotide sequence | Mycobacterium tuberculosis |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
6.3.2.1 | PanC | - |
Mycobacterium tuberculosis |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
6.3.2.1 | 3.4 | - |
beta-Alanine | 25°C, pH 7.8 | Mycobacterium tuberculosis | |
6.3.2.1 | 3.4 | - |
D-pantoate | 25°C, pH 7.8 | Mycobacterium tuberculosis |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
6.3.2.1 | 4.5 | - |
pantothenate | 25°C, pH 7.8, vs. beta-alanine | Mycobacterium tuberculosis | |
6.3.2.1 | 5.7 | - |
pantothenate | 25°C, pH 7.8, vs. D-pantoate | Mycobacterium tuberculosis | |
6.3.2.1 | 7.6 | - |
pantothenate | 25°C, pH 7.8, vs. ATP | Mycobacterium tuberculosis |