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Literature summary extracted from
- Membrane lipids have multiple effects on interfacial catalysis by a phosphatidic acid-preferring phospholipase A1 from bovine testis (2000), Biochemistry, 39, 9335-9344.
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 3.1.1.32 | membrane lipids increase stability | Bos taurus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.1.32 | cytosol | - |
Bos taurus | 5829 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.32 | phosphatidic acid + H2O | Bos taurus | - |
2-acylglycerophosphatidic acid + a carboxylate | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.1.32 | Bos taurus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.1.32 | Superdex 200, partially purified | Bos taurus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.1.32 | testis | - |
Bos taurus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.32 | phosphatidic acid + H2O | - |
Bos taurus | 2-acylglycerophosphatidic acid + a carboxylate | - |
? | |
| 3.1.1.32 | phosphatidic acid + H2O | the catalytic preference for phosphatidic acid increases in the presence of membranes containing cholesterol, diacylglycerol, sn-1-stearoyl-2-arachidonoylphosphatidylethanolamine instead of sn-1-palmitoyl-2-oleeoylphosphatidylethanolamine and 10 mol% phosphatidic acid per 100 mol% total phosphoglycerides | Bos taurus | 2-acylglycerophosphatidic acid + a carboxylate | - |
? | |
| 3.1.1.32 | phosphatidylcholine + H2O | 18fold lower initial rate than with phosphatidic acid | Bos taurus | 2-acylglycerophosphocholine + a carboxylate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.1.32 | PA-PLA1 | - |
Bos taurus |
| 3.1.1.32 | phosphatidic acid-preferring phospholipase A1 | - |
Bos taurus |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.32 | 37 | - |
75% loss of activity after 1 h, only little loss of activity in the presence of sn-1-alkyl-2-oleoyl or lysophosphatidic acid containing membranes | Bos taurus |
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Release 2023.1 (January 2023)
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