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Literature summary extracted from

  • Nigou, J.; Besra, G.S.
    Characterization and regulation of inositol monophosphatase activity in Mycobacterium smegmatis (2002), Biochem. J., 361, 385-390.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.25 Li+ 50% inhibition at 0.8 mM, also able to inhibit cell growth Mycolicibacterium smegmatis
3.1.3.25 myo-inositol product inhibition, competitive Mycolicibacterium smegmatis
3.1.3.25 Na+ 50% inhibition at 70 mM Mycolicibacterium smegmatis
3.1.3.25 phosphate product inhibition, competitive Mycolicibacterium smegmatis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.25 3.2
-
Mg2+ pH 7.5, 37°C Mycolicibacterium smegmatis
3.1.3.25 66
-
myo-inositol 1-phosphate pH 7.5, 37°C Mycolicibacterium smegmatis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.25 Mg2+ required, highest activity at 6 mM Mg2+, inhibitory at higher concentrations Mycolicibacterium smegmatis
3.1.3.25 Zn2+ no effect between 0.01-10 mM Mycolicibacterium smegmatis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.25 myo-inositol 1-phosphate + H2O Mycolicibacterium smegmatis key metabolic step, de novo synthesis of myo-inositol, phosphatidylinositol is essential of growth myo-inositol + phosphate
-
?
3.1.3.25 myo-inositol 1-phosphate + H2O Mycolicibacterium smegmatis mc(2)155 key metabolic step, de novo synthesis of myo-inositol, phosphatidylinositol is essential of growth myo-inositol + phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.25 Mycolicibacterium smegmatis
-
-
-
3.1.3.25 Mycolicibacterium smegmatis mc(2)155
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.3.25 additional information
-
when grown on glycerol highest activity at the end of exponential growth phase, when grown on glucose highest activity in the middle of exponential growth phase Mycolicibacterium smegmatis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.25 myo-inositol 1-phosphate + H2O
-
Mycolicibacterium smegmatis myo-inositol + phosphate
-
?
3.1.3.25 myo-inositol 1-phosphate + H2O key metabolic step, de novo synthesis of myo-inositol, phosphatidylinositol is essential of growth Mycolicibacterium smegmatis myo-inositol + phosphate
-
?
3.1.3.25 myo-inositol 1-phosphate + H2O
-
Mycolicibacterium smegmatis mc(2)155 myo-inositol + phosphate
-
?
3.1.3.25 myo-inositol 1-phosphate + H2O key metabolic step, de novo synthesis of myo-inositol, phosphatidylinositol is essential of growth Mycolicibacterium smegmatis mc(2)155 myo-inositol + phosphate
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.25 7.5
-
-
Mycolicibacterium smegmatis

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.1.3.25 6 10
-
Mycolicibacterium smegmatis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.3.25 2.7
-
phosphate pH 7.5, 37°C Mycolicibacterium smegmatis
3.1.3.25 39
-
myo-inositol pH 7.5, 37°C Mycolicibacterium smegmatis