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Literature summary extracted from

  • Jowsey, I.R.; Thomson, A.M.; Flanagan, J.U.; Murdock, P.R.; Moore, G.B.T.; Meyer, D.J.; Murphy, G.J.; Smith, S.A.; Hayes, J.D.
    Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases (2001), Biochem. J., 359, 507-516.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.3.99.2 expression of cDNA in Escherichia coli Homo sapiens
5.3.99.2 expression of cDNA in Escherichia coli Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.3.99.2 0.2
-
 glutathione
-
 Homo sapiens
5.3.99.2 0.2
-
 (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
-
 Homo sapiens
5.3.99.2 0.2
-
 (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
-
 Rattus norvegicus
5.3.99.2 0.3
-
 glutathione
-
 Rattus norvegicus
5.3.99.2 0.3
-
 glutathione glutathione S-transferase activity Rattus norvegicus
5.3.99.2 3.2
-
 1-chloro-2,4-dinitrobenzene
-
 Homo sapiens
5.3.99.2 5
-
 1-chloro-2,4-dinitrobenzene
-
 Rattus norvegicus
5.3.99.2 8
-
 glutathione glutathione S-transferase activity Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.3.99.2 23000
-
 x * 23000, SDS-PAGE Homo sapiens
5.3.99.2 23000
-
 x * 23000, SDS-PAGE Rattus norvegicus
5.3.99.2 23298
-
 x * 23298, deduced from nucleotide sequence Rattus norvegicus
5.3.99.2 23359
-
 x * 23359, deduced from nucleotide sequence Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.99.2 (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate Homo sapiens
-
 (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
-
 ?
5.3.99.2 (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate Rattus norvegicus
-
 (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
-
 ?
5.3.99.2 1-bromo-2,4-dinitrobenzene + glutathione Homo sapiens
-
 ?
-
 ?
5.3.99.2 1-bromo-2,4-dinitrobenzene + glutathione Rattus norvegicus
-
 ?
-
 ?
5.3.99.2 1-chloro-2,4-dinitrobenzene + glutathione Homo sapiens
-
 ?
-
 ?
5.3.99.2 1-chloro-2,4-dinitrobenzene + glutathione Rattus norvegicus
-
 ?
-
 ?
5.3.99.2 1-fluoro-2,4-dinitrobenzene + glutathione Homo sapiens
-
 ?
-
 ?
5.3.99.2 1-fluoro-2,4-dinitrobenzene + glutathione Rattus norvegicus
-
 ?
-
 ?
5.3.99.2 1-iodo-2,4-dinitrobenzene + glutathione Homo sapiens
-
 ?
-
 ?
5.3.99.2 1-iodo-2,4-dinitrobenzene + glutathione Rattus norvegicus
-
 ?
-
 ?
5.3.99.2 allyl isothiocyanate + glutathione Homo sapiens
-
 ?
-
 ?
5.3.99.2 allyl isothiocyanate + glutathione Rattus norvegicus
-
 ?
-
 ?
5.3.99.2 benzyl isothiocyanate + glutathione Homo sapiens
-
 ?
-
 ?
5.3.99.2 benzyl isothiocyanate + glutathione Rattus norvegicus
-
 ?
-
 ?
5.3.99.2 cumene hydroperoxide + 2 GSH Homo sapiens
-
 cumene hydroxide + GSSG + H2O
-
 ?
5.3.99.2 cumene hydroperoxide + 2 GSH Rattus norvegicus
-
 cumene hydroxide + GSSG + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.2 Homo sapiens
-
-
-
5.3.99.2 Rattus norvegicus O35543
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.3.99.2 recombinant PGDS Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.2 (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
-
 Homo sapiens (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
-
 ?
5.3.99.2 (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
-
 Rattus norvegicus (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
-
 ?
5.3.99.2 1-bromo-2,4-dinitrobenzene + glutathione
-
 Homo sapiens ?
-
 ?
5.3.99.2 1-bromo-2,4-dinitrobenzene + glutathione
-
 Rattus norvegicus ?
-
 ?
5.3.99.2 1-chloro-2,4-dinitrobenzene + glutathione
-
 Homo sapiens ?
-
 ?
5.3.99.2 1-chloro-2,4-dinitrobenzene + glutathione
-
 Rattus norvegicus ?
-
 ?
5.3.99.2 1-fluoro-2,4-dinitrobenzene + glutathione
-
 Homo sapiens ?
-
 ?
5.3.99.2 1-fluoro-2,4-dinitrobenzene + glutathione
-
 Rattus norvegicus ?
-
 ?
5.3.99.2 1-iodo-2,4-dinitrobenzene + glutathione
-
 Homo sapiens ?
-
 ?
5.3.99.2 1-iodo-2,4-dinitrobenzene + glutathione
-
 Rattus norvegicus ?
-
 ?
5.3.99.2 allyl isothiocyanate + glutathione
-
 Homo sapiens ?
-
 ?
5.3.99.2 allyl isothiocyanate + glutathione
-
 Rattus norvegicus ?
-
 ?
5.3.99.2 benzyl isothiocyanate + glutathione
-
 Homo sapiens ?
-
 ?
5.3.99.2 benzyl isothiocyanate + glutathione
-
 Rattus norvegicus ?
-
 ?
5.3.99.2 cumene hydroperoxide + 2 GSH
-
 Homo sapiens cumene hydroxide + GSSG + H2O
-
 ?
5.3.99.2 cumene hydroperoxide + 2 GSH
-
 Rattus norvegicus cumene hydroxide + GSSG + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
5.3.99.2 ? x * 23000, SDS-PAGE Homo sapiens
5.3.99.2 ? x * 23000, SDS-PAGE Rattus norvegicus
5.3.99.2 ? x * 23298, deduced from nucleotide sequence Rattus norvegicus
5.3.99.2 ? x * 23359, deduced from nucleotide sequence Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
5.3.99.2 glutathione-dependent prostaglandin D2 synthase
-
 Homo sapiens
5.3.99.2 glutathione-dependent prostaglandin D2 synthase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
5.3.99.2 glutathione
-
 Homo sapiens
5.3.99.2 glutathione
-
 Rattus norvegicus