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Literature summary extracted from

  • Vessey, D.A.; Kelley, M.
    Characterization of the reaction mechanism for the XL-I form of bovine liver xenobiotic/medium-chain fatty acid:CoA ligase (2001), Biochem. J., 357, 283-288.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.2.1.2 AMP product inhibitor Bos taurus
6.2.1.2 benzoate competitive inhibitor of butyrate Bos taurus
6.2.1.2 benzoyl-CoA product inhibitor Bos taurus
6.2.1.2 Butyrate competitive inhibitor of benzoate Bos taurus
6.2.1.2 butyryl-CoA competitive inhibitor with respect to both butyrate and benzoate Bos taurus
6.2.1.2 diphosphate weak product inhibitor, competitive with respect to CoA and mixed inhibitor with respect to benzoate. Mixed type inhibitor with respect to CoA in butyrate:CoA ligase activity Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.2.1.2 0.007
-
benzoate
-
Bos taurus
6.2.1.2 0.06
-
CoA
-
Bos taurus
6.2.1.2 0.2
-
ATP
-
Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.2.1.2 mitochondrion
-
Bos taurus 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.2.1.2 Mg2+ activates Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.2 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.2.1.2
-
Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.2 liver
-
Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.2 ATP + benzoate + CoA bi uni uni bi ping pong mechanism with ATP binding first, followed in order by benzoate binding, diphosphate release, CoA binding, benzoyl-CoA release and AMP release Bos taurus AMP + diphosphate + benzoyl-CoA
-
?
6.2.1.2 ATP + butyrate + CoA
-
Bos taurus AMP + diphosphate + butyryl-CoA
-
?

Synonyms

EC Number Synonyms Comment Organism
6.2.1.2 xenobiotic/medium-chain fatty acid:CoA ligase
-
Bos taurus