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Literature summary extracted from

  • Kerovuo, J.; Rouvinen, J.; Hatzack, F.
    Analysis of myo-inositol hexakisphosphate hydrolysis by Bacillus phytase: indication of a novel reaction mechanism (2000), Biochem. J., 352, 623-628.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.8 additional information no inhibition by myo-inositol hexasulfate up to 2 mM, no inhibition by F- up to 10 mM Bacillus subtilis
3.1.3.8 vanadate weak Bacillus subtilis

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.8 Bacillus subtilis
-
-
-
3.1.3.8 Bacillus subtilis VTT E-68013
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.8 myo-inositol hexakisphosphate + H2O
-
Bacillus subtilis D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate after 10 min D-myo-inositol 1,2,4,5,6-pentakisphosphate is the major degradation product, accompanied by small amounts of D-myo-inositol 1,2,3,4,6-pentakisphosphate, D-myo-inositol 2,4,5,6-tetrakisphosphate and D-myo-inositol 1,2,35-tetrakisphosphate. After 30 min, the quantity of D-myo-inositol 1,2,4,5,6-pentakisphosphate decreases and the levels of D-myo-inositol 2,4,5,6-tetrakisphosphate and D-myo-inositol 1,2,35-tetrakisphosphate increases. After 90 min the major products are Ins(1,3,5) P3 and Ins(2,4,6)P3 ?
3.1.3.8 myo-inositol hexakisphosphate + H2O
-
Bacillus subtilis VTT E-68013 D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate after 10 min D-myo-inositol 1,2,4,5,6-pentakisphosphate is the major degradation product, accompanied by small amounts of D-myo-inositol 1,2,3,4,6-pentakisphosphate, D-myo-inositol 2,4,5,6-tetrakisphosphate and D-myo-inositol 1,2,35-tetrakisphosphate. After 30 min, the quantity of D-myo-inositol 1,2,4,5,6-pentakisphosphate decreases and the levels of D-myo-inositol 2,4,5,6-tetrakisphosphate and D-myo-inositol 1,2,35-tetrakisphosphate increases. After 90 min the major products are Ins(1,3,5) P3 and Ins(2,4,6)P3 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.8 PhyC
-
Bacillus subtilis