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Literature summary extracted from

  • Krause, T.; Luersen, K.; Wrenger, C.; Gilberger, T.W.; Muller, S.; Walter, R.D.
    The ornithine decarboxylase domain of the bifunctional ornithine decarboxylase/S-adenosylmethionine decarboxylase of Plasmodium falciparum: recombinant expression and catalytic properties of two different constructs (2000), Biochem. J., 352, 287-292.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.17 expression of ODC domain, i.e. rPfODC, and ODC domain in conjunction with the preceeding part of the hinge region of the bifunctional ODC/AdoMetDC, i.e.rPfHinge-ODC, in Escherichia coli Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.17 alpha-difluoroornithine
-
 Plasmodium falciparum
4.1.1.17 CGP52622A 3-amino-oxy-1-propanamine analog, 0.00006 mM, 50% inhibition of recombinant Pf-Hinge-ODC Plasmodium falciparum
4.1.1.17 CGP54619A 3-amino-oxy-1-propanamine analog, 0.000025 mM, 50% inhibition of recombinant Pf-Hinge-ODC Plasmodium falciparum
4.1.1.17 putrescine
-
 Plasmodium falciparum
4.1.1.17 spermidine 1 mM, 61% inhibition of recombinant-Hinge-ODC and 63% inhibition of recombinant PfODC Plasmodium falciparum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.17 0.047
-
 L-ornithine recombinant Pf-Hinge-ODC Plasmodium falciparum
4.1.1.17 0.16
-
 L-ornithine recombinant PfODC domain Plasmodium falciparum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.17 L-ornithine Plasmodium falciparum
-
 putrescine + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.17 Plasmodium falciparum
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.17 recombinant PfODC and Pf-Hinge-ODC Plasmodium falciparum

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.17 0.0043
-
 recombinant pF-Hinge-ODC Plasmodium falciparum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.17 L-ornithine
-
 Plasmodium falciparum putrescine + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.17 ODC
-
 Plasmodium falciparum

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.1.1.17 0.003
-
 L-ornithine recombinant PfODC domain Plasmodium falciparum
4.1.1.17 0.006
-
 L-ornithine recombinant Pf-Hinge-ODC Plasmodium falciparum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.17 7 8 recombinant PfODC domain Plasmodium falciparum
4.1.1.17 7.5 8.5 recombinant Pf-Hinge-ODC Plasmodium falciparum

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.1.1.17 0.000008
-
 CGP54619A
-
 Plasmodium falciparum
4.1.1.17 0.00002
-
 CGP52622A
-
 Plasmodium falciparum
4.1.1.17 0.05
-
 putrescine recombinant Pf-Hinge-ODC Plasmodium falciparum
4.1.1.17 0.09
-
 alpha-difluoroornithine recombinant Pf-Hinge-ODC Plasmodium falciparum
4.1.1.17 0.16
-
 putrescine recombinant PfODC domain Plasmodium falciparum