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Literature summary extracted from

  • Yiallouros, I.; Vassiliou, S.; Yiotakis, A.; Zwilling, R.; Stoecker, W.; Dive, V.
    Phosphinic peptides, the first potent inhibitors of astacin, behave as extremely slow-binding inhibitors (1998), Biochem. J., 331, 375-379.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.21 9-fluorenylmethyloxycarbonyl-KFPCAPLV-OH
-
 Astacus astacus
3.4.24.21 9-fluorenylmethyloxycarbonyl-PKFPCAPLV-OH
-
 Astacus astacus
3.4.24.21 9fluorenylmethyloxycarbonyl-F-PSI[PO2CH2]-APLV-OH
-
 Astacus astacus
3.4.24.21 9fluorenylmethyloxycarbonyl-FPCAPLVOH
-
 Astacus astacus
3.4.24.21 9fluorenylmethyloxycarbonyl-KF-PSI[PO2CH2]-APLV-OH
-
 Astacus astacus
3.4.24.21 9fluorenylmethyloxycarbonyl-PKF-PSI[PO2CH2]-APLV-OH
-
 Astacus astacus
3.4.24.21 benzyloxycarbonyl-PKF-PSI[PO2CH2]-AGP-O-methyl
-
 Astacus astacus
3.4.24.21 benzyloxycarbonyl-PKF-PSI[PO2CH2]-AP-O-methyl
-
 Astacus astacus
3.4.24.21 benzyloxycarbonyl-PKF-PSI[PO2CH2]-APL-O-methyl
-
 Astacus astacus
3.4.24.21 benzyloxycarbonyl-PKF-PSI[PO2CH2]-GPL-O-methyl
-
 Astacus astacus
3.4.24.21 benzyloxycarbonyl-PKK-PSI[PO2CH2]-APLV-O-methyl
-
 Astacus astacus
3.4.24.21 benzyloxycarbonyl-Pro-Lys-Phe-PSI[PO2CH2]Ala-Pro-O-methyl
-
 Astacus astacus
3.4.24.21 fluorenylmethyloxycarbonyl-Pro-Lys-Phe-PSI[PO2CH2]Ala-Pro-Leu-Val
-
 Astacus astacus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.21 Zn2+ zinc endopeptidase Astacus astacus

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.21 Astacus astacus
-
 crayfish
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.21
-
 Astacus astacus

Synonyms

EC Number Synonyms Comment Organism
3.4.24.21 astacin
-
 Astacus astacus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.24.21 0.000036
-
 9-fluorenylmethyloxycarbonyl-PKFPCAPLV-OH pH 8.0, 25°C Astacus astacus
3.4.24.21 0.000042
-
 fluorenylmethyloxycarbonyl-Pro-Lys-Phe-PSI[PO2CH2]Ala-Pro-Leu-Val pH 8.0, 25°C Astacus astacus
3.4.24.21 0.0018
-
 9-fluorenylmethyloxycarbonyl-KFPCAPLV-OH pH 8.0, 25°C Astacus astacus
3.4.24.21 0.0036
-
 9fluorenylmethyloxycarbonyl-FPCAPLVOH pH 8.0, 25°C Astacus astacus
3.4.24.21 0.01
-
 benzyloxycarbonyl-PKF-PSI[PO2CH2]-APL-O-methyl pH 8.0, 25°C Astacus astacus
3.4.24.21 0.011
-
 benzyloxycarbonyl-PKK-PSI[PO2CH2]-APLV-O-methyl pH 8.0, 25°C Astacus astacus
3.4.24.21 0.014
-
 benzyloxycarbonyl-Pro-Lys-Phe-PSI[PO2CH2]Ala-Pro-O-methyl pH 8.0, 25°C Astacus astacus
3.4.24.21 0.58
-
 benzyloxycarbonyl-PKF-PSI[PO2CH2]-GPL-O-methyl pH 8.0, 25°C Astacus astacus