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Literature summary extracted from

  • Comtesse, N.; Maldener, E.; Meese, E.
    Identification of a nuclear variant of MGEA5, a cytoplasmic hyaluronidase and a beta-N-acetylglucosaminidase (2001), Biochem. Biophys. Res. Commun., 283, 634-640.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.2.1.35 gene mgea5, DNA sequence determination and analysis, genomic organization on chromosome 10, 2 splice variants, one missing a putative acetyltransferase domain of the enzyme Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.35 cytoskeleton 130 kDa enzyme form Homo sapiens 5856
-
3.2.1.35 cytosol 130 kDa enzyme form Homo sapiens 5829
-
3.2.1.35 membrane 130 kDa enzyme form Homo sapiens 16020
-
3.2.1.35 nucleus 75 kDa enzyme form Homo sapiens 5634
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.2.1.35 75000
-
 x * 130000, enzyme form 1, SDS-PAGE, x * 75000, enzyme form 2, SDS-PAGE Homo sapiens
3.2.1.35 130000
-
 x * 130000, enzyme form 1, SDS-PAGE, x * 75000, enzyme form 2, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.35 Homo sapiens O60502 gene mgea5, bifunctional enzyme possessing hyaluronidase and beta-N-acetylglucoaminidase activities
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.2.1.35 proteolytic modification posttranslational modification of a larger protein of 130 kDa to a 75 kDa form Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.35 astrocytoma cell primary pilocytic Homo sapiens
-
3.2.1.35 brain
-
 Homo sapiens
-
3.2.1.35 colon
-
 Homo sapiens
-
3.2.1.35 gall bladder
-
 Homo sapiens
-
3.2.1.35 heart
-
 Homo sapiens
-
3.2.1.35 liver
-
 Homo sapiens
-
3.2.1.35 lung
-
 Homo sapiens
-
3.2.1.35 lung carcinoma cell
-
 Homo sapiens
-
3.2.1.35 meningioma cell
-
 Homo sapiens
-
3.2.1.35 additional information both splice variants of gene mgea5 are ubiquitously expressed in various tissues Homo sapiens
-
3.2.1.35 placenta
-
 Homo sapiens
-
3.2.1.35 skeletal muscle
-
 Homo sapiens
-
3.2.1.35 stomach
-
 Homo sapiens
-
3.2.1.35 TX3868 cell glioblastoma cell line Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.35 hyaluronate + H2O from umbilical cord Homo sapiens N-acetyl-beta-D-glucosamine + D-glucuronate + ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.2.1.35 ? x * 130000, enzyme form 1, SDS-PAGE, x * 75000, enzyme form 2, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.2.1.35 hyaluronidase
-
 Homo sapiens
3.2.1.35 MGEA5
-
 Homo sapiens