Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Clottes, E.; Middleditch, C.; Burchell, A.
    Rat liver glucose-6-phosphatase system: light scattering and chemical characterization (2002), Arch. Biochem. Biophys., 408, 33-41.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.9 2-nitro-5-thiocyano-benzoic acid
-
Rattus norvegicus
3.1.3.9 4-maleimidylstilbene-2,2'-disulfonic acid
-
Rattus norvegicus
3.1.3.9 5-((((iodoacetyl)amino)ethyl)amino)naphthalene-1-sulfonic acid
-
Rattus norvegicus
3.1.3.9 DTNB
-
Rattus norvegicus
3.1.3.9 NEM
-
Rattus norvegicus
3.1.3.9 p-hydroxy mercury-phenylsulfonate
-
Rattus norvegicus
3.1.3.9 p-hydroxy mercurybenzoic acid
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.9 endoplasmic reticulum membrane
-
Rattus norvegicus 5789
-
3.1.3.9 microsome
-
Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.9 D-glucose 6-phosphate + H2O Rattus norvegicus the enzyme is required for the final steps of glycogenolysis and gluconeogenesis D-glucose + phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.9 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.3.9 additional information chemical modification of thiol groups belonging to proteins involved in the enzyme system by DTNB, NTCB and IAEDANS decrease the enzyme activity, the incubation with phosphate preventes the loss of activity, the addition of 2-mercaptoethanol allows a 50% restoration of the initial activity, however chemical modification of thiol groups by pHMPS, pHMB, AMSDS and NEM decrease the enzyme activity Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.9 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.9 D-glucose 6-phosphate + H2O
-
Rattus norvegicus D-glucose + phosphate
-
?
3.1.3.9 D-glucose 6-phosphate + H2O the enzyme is required for the final steps of glycogenolysis and gluconeogenesis Rattus norvegicus D-glucose + phosphate
-
?

Subunits

EC Number Subunits Comment Organism
3.1.3.9 More the enzyme is multiprotein system, the transmembrane catalytic subunit and the D-glucose 6-phosphate translocase have reactive thiol groups facing the cytosol Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.3.9 0.5
-
NEM
-
Rattus norvegicus
3.1.3.9 0.5
-
4-maleimidylstilbene-2,2'-disulfonic acid
-
Rattus norvegicus
3.1.3.9 0.6
-
DTNB
-
Rattus norvegicus
3.1.3.9 0.8
-
5-((((iodoacetyl)amino)ethyl)amino)naphthalene-1-sulfonic acid
-
Rattus norvegicus
3.1.3.9 2
-
2-nitro-5-thiocyano-benzoic acid
-
Rattus norvegicus