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Literature summary extracted from

  • Feng, Z.; Barletta, R.G.
    Roles of Mycobacterium smegmatis D-alanine:D-alanine ligase and D-alanine racemase in the mechanisms of action of and resistance to the peptidoglycan inhibitor D-cycloserine (2003), Antimicrob. Agents Chemother., 47, 283-291.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.3.2.4 overexpression of Ddl in Mycobacterium smegmatis Mycobacterium tuberculosis
6.3.2.4 overexpression of Ddl in Mycobacterium smegmatis Mycolicibacterium smegmatis

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.2.4 D-cycloserine 0.2 mg/ml, approx. 60% inhibition, 0.8 mg/ml, approx. 95% inhibition Mycobacterium tuberculosis
6.3.2.4 D-cycloserine 0.2 mg/ml, approx. 50% inhibition, 0.8 mg/ml, approx. 80% inhibition Mycolicibacterium smegmatis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.4 ATP + D-alanine Mycobacterium tuberculosis
-
 ADP + phosphate + D-alanyl-D-alanine
-
 ?
6.3.2.4 ATP + D-alanine Mycolicibacterium smegmatis
-
 ADP + phosphate + D-alanyl-D-alanine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.4 Mycobacterium tuberculosis
-
-
-
6.3.2.4 Mycolicibacterium smegmatis Q9ZGN0
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.4 ATP + D-alanine
-
 Mycobacterium tuberculosis ADP + phosphate + D-alanyl-D-alanine
-
 ?
6.3.2.4 ATP + D-alanine
-
 Mycolicibacterium smegmatis ADP + phosphate + D-alanyl-D-alanine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.2.4 Ddl
-
 Mycobacterium tuberculosis
6.3.2.4 Ddl
-
 Mycolicibacterium smegmatis