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Literature summary extracted from

  • Exton, J.H.
    Phospholipase D (2000), Ann. N. Y. Acad. Sci., 905, 61-68.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.4 additional information overview on activating compounds and mechanism Mammalia

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.4 additional information overview on inhibitory compounds and mechanism Mammalia

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.4 caveolae PLD2 Mammalia
-
-
3.1.4.4 endoplasmic reticulum PLD1 Mammalia 5783
-
3.1.4.4 endosome late endosome, PLD1 Mammalia 5768
-
3.1.4.4 Golgi apparatus PLD1 Mammalia 5794
-
3.1.4.4 plasma membrane PLD2 Mammalia 5886
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.4 Mammalia
-
 isozymes PLD1, PLD2, regulation of enzyme activity
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.4.4 phosphoprotein PLD1, regulated by protein kinase alpha, beta, gamma, activation in vitro does not require phosphorylation, but tyrosine phosphorylation occurs in vivo, overview Mammalia

Reaction

EC Number Reaction Comment Organism Reaction ID
3.1.4.4 a phosphatidylcholine + H2O = choline + a phosphatidate mechanism Mammalia
a

Subunits

EC Number Subunits Comment Organism
3.1.4.4 additional information overview on subunit domains Mammalia